Associations between functional connectivity dynamics and BOLD dynamics are heterogeneous across brain networks

Zening Fu, Yiheng Tu, Xin Di, Bharat B. Biswal, Vince Daniel Calhoun, Zhiguo Zhang

Research output: Contribution to journalArticle

Abstract

Functional brain imaging has revealed two types of dynamic patterns of brain in the resting-state: the dynamics of spontaneous brain activities and the dynamics of functional interconnections between spontaneous brain activities. Although these two types of brain dynamics are usually investigated separately in the literature, recent functional magnetic resonance imaging (fMRI) studies have shown that they exhibit similar spatial patterns, suggesting the dynamics of spontaneous brain activities and the dynamics of their interconnections are associated with each other. In this study, we characterized the local blood oxygenation level dependent (BOLD) dynamics and the functional connectivity dynamics (FCD) in the resting-state, and then investigated their between-region associations. Time-varying FC was estimated as time-varying correlation coefficients using a sliding-window method, and the temporal variability of BOLD and time-varying FC were used to quantify the BOLD dynamics and the FCD, respectively. Our results showed that the BOLD dynamics and the FCD exhibit similar spatial patterns, and they are significantly associated across brain regions. Importantly, such associations are opposite for different types of FC (e.g., within-network FCD are negatively correlated with the BOLD dynamics but the between-network FCD are positively correlated with the BOLD dynamics), and they are spatially heterogeneous across brain networks. The identified heterogeneous associations between the BOLD dynamics and the FCD appear to convey related or even distinct information and might underscore the potential mechanism of brain coordination and co-evolution.

Original languageEnglish (US)
Article number593
JournalFrontiers in Human Neuroscience
Volume11
DOIs
StatePublished - Dec 7 2017
Externally publishedYes

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Brain
Functional Neuroimaging
Magnetic Resonance Imaging

Keywords

  • Associations between brain dynamics
  • BOLD dynamic
  • Functional connectivity dynamic
  • Resting-state
  • Spatial heterogeneity

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Associations between functional connectivity dynamics and BOLD dynamics are heterogeneous across brain networks. / Fu, Zening; Tu, Yiheng; Di, Xin; Biswal, Bharat B.; Calhoun, Vince Daniel; Zhang, Zhiguo.

In: Frontiers in Human Neuroscience, Vol. 11, 593, 07.12.2017.

Research output: Contribution to journalArticle

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