Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068

Elizabeth Fearon, Richard D. Wiggins, Audrey E. Pettifor, Catherine MacPhail, Kathleen Kahn, Amanda Selin, F. Xavier Gómez-Olivé, Sinéad Delany-Moretlwe, Estelle Piwowar-Manning, Oliver B. Laeyendecker, James R. Hargreaves

Research output: Contribution to journalArticle

Abstract

Introduction: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. We investigated associations between young women's friendships and their Herpes Simplex Virus Type 2 (HSV-2) and HIV infection status in rural South Africa. Methods: Our study is a cross-sectional, egocentric network analysis. In 2011 to 2012, we tested 13- to 20-year-old young women for HIV and HSV-2, and collected descriptions of five friendships for each. We generated summary measures describing friend socio-demographic characteristics and the number of friends perceived to have had sex. We used logistic regression to analyse associations between friend characteristics and participant HIV and HSV-2 infection, excluding likely perinatal HIV infections. Results: There were 2326 participants included in the study sample, among whom HIV and HSV-2 prevalence were 3.3% and 4.6% respectively. Adjusted for participant and friend socio-demographic characteristics, each additional friend at least one year older than the participant was associated with raised odds of HIV (odds ratio (OR) = 1.37, 95% CI 1.03 to 1.82) and HSV-2 (adjusted OR=1.41, 95% CI 1.18 to 1.69). Each additional friend perceived to have ever had sex also raised the odds of HIV (OR = 1.29, 95% CI 1.03 to 1.63) and HSV-2 (OR=1.18, 95% CI 1.03 to 1.35). Discussion: We found good evidence that a greater number of older friends and friends perceived to have had sex were associated with increased risk for HSV-2 and HIV infection among young women. Conclusions: The characteristics of young women's friendships could contribute to their risk of HIV infection. The extent to which policies or programmes influence age-mixing and young women's normative environments should be considered.

Original languageEnglish (US)
Article numbere25029
JournalJournal of the International AIDS Society
Volume20
Issue number4
DOIs
StatePublished - Dec 1 2017

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Human Herpesvirus 2
HIV
HIV Infections
Odds Ratio
South Africa
Demography
Peer Group
Sexual Partners
Reproductive Health
Health Behavior
Condoms
Social Support
Logistic Models
Regression Analysis

Keywords

  • adolescents
  • friendships
  • HIV
  • HSV-2
  • peer influence
  • social networks
  • social norms
  • South Africa
  • young women

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Fearon, E., Wiggins, R. D., Pettifor, A. E., MacPhail, C., Kahn, K., Selin, A., ... Hargreaves, J. R. (2017). Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068. Journal of the International AIDS Society, 20(4), [e25029]. https://doi.org/10.1002/jia2.25029

Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068. / Fearon, Elizabeth; Wiggins, Richard D.; Pettifor, Audrey E.; MacPhail, Catherine; Kahn, Kathleen; Selin, Amanda; Gómez-Olivé, F. Xavier; Delany-Moretlwe, Sinéad; Piwowar-Manning, Estelle; Laeyendecker, Oliver B.; Hargreaves, James R.

In: Journal of the International AIDS Society, Vol. 20, No. 4, e25029, 01.12.2017.

Research output: Contribution to journalArticle

Fearon, E, Wiggins, RD, Pettifor, AE, MacPhail, C, Kahn, K, Selin, A, Gómez-Olivé, FX, Delany-Moretlwe, S, Piwowar-Manning, E, Laeyendecker, OB & Hargreaves, JR 2017, 'Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068', Journal of the International AIDS Society, vol. 20, no. 4, e25029. https://doi.org/10.1002/jia2.25029
Fearon, Elizabeth ; Wiggins, Richard D. ; Pettifor, Audrey E. ; MacPhail, Catherine ; Kahn, Kathleen ; Selin, Amanda ; Gómez-Olivé, F. Xavier ; Delany-Moretlwe, Sinéad ; Piwowar-Manning, Estelle ; Laeyendecker, Oliver B. ; Hargreaves, James R. / Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068. In: Journal of the International AIDS Society. 2017 ; Vol. 20, No. 4.
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abstract = "Introduction: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. We investigated associations between young women's friendships and their Herpes Simplex Virus Type 2 (HSV-2) and HIV infection status in rural South Africa. Methods: Our study is a cross-sectional, egocentric network analysis. In 2011 to 2012, we tested 13- to 20-year-old young women for HIV and HSV-2, and collected descriptions of five friendships for each. We generated summary measures describing friend socio-demographic characteristics and the number of friends perceived to have had sex. We used logistic regression to analyse associations between friend characteristics and participant HIV and HSV-2 infection, excluding likely perinatal HIV infections. Results: There were 2326 participants included in the study sample, among whom HIV and HSV-2 prevalence were 3.3{\%} and 4.6{\%} respectively. Adjusted for participant and friend socio-demographic characteristics, each additional friend at least one year older than the participant was associated with raised odds of HIV (odds ratio (OR) = 1.37, 95{\%} CI 1.03 to 1.82) and HSV-2 (adjusted OR=1.41, 95{\%} CI 1.18 to 1.69). Each additional friend perceived to have ever had sex also raised the odds of HIV (OR = 1.29, 95{\%} CI 1.03 to 1.63) and HSV-2 (OR=1.18, 95{\%} CI 1.03 to 1.35). Discussion: We found good evidence that a greater number of older friends and friends perceived to have had sex were associated with increased risk for HSV-2 and HIV infection among young women. Conclusions: The characteristics of young women's friendships could contribute to their risk of HIV infection. The extent to which policies or programmes influence age-mixing and young women's normative environments should be considered.",
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AU - Kahn, Kathleen

AU - Selin, Amanda

AU - Gómez-Olivé, F. Xavier

AU - Delany-Moretlwe, Sinéad

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N2 - Introduction: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. We investigated associations between young women's friendships and their Herpes Simplex Virus Type 2 (HSV-2) and HIV infection status in rural South Africa. Methods: Our study is a cross-sectional, egocentric network analysis. In 2011 to 2012, we tested 13- to 20-year-old young women for HIV and HSV-2, and collected descriptions of five friendships for each. We generated summary measures describing friend socio-demographic characteristics and the number of friends perceived to have had sex. We used logistic regression to analyse associations between friend characteristics and participant HIV and HSV-2 infection, excluding likely perinatal HIV infections. Results: There were 2326 participants included in the study sample, among whom HIV and HSV-2 prevalence were 3.3% and 4.6% respectively. Adjusted for participant and friend socio-demographic characteristics, each additional friend at least one year older than the participant was associated with raised odds of HIV (odds ratio (OR) = 1.37, 95% CI 1.03 to 1.82) and HSV-2 (adjusted OR=1.41, 95% CI 1.18 to 1.69). Each additional friend perceived to have ever had sex also raised the odds of HIV (OR = 1.29, 95% CI 1.03 to 1.63) and HSV-2 (OR=1.18, 95% CI 1.03 to 1.35). Discussion: We found good evidence that a greater number of older friends and friends perceived to have had sex were associated with increased risk for HSV-2 and HIV infection among young women. Conclusions: The characteristics of young women's friendships could contribute to their risk of HIV infection. The extent to which policies or programmes influence age-mixing and young women's normative environments should be considered.

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