TY - JOUR
T1 - Associations between dietary patterns and subclinical cardiac injury
T2 - An observational analysis from the DASH trial
AU - Juraschek, Stephen P.
AU - Kovell, Lara C.
AU - Appel, Lawrence J.
AU - Miller, Edgar R.
AU - Sacks, Frank M.
AU - Christenson, Robert H.
AU - Rebuck, Heather
AU - Chang, Alexander R.
AU - Mukamal, Kenneth J.
N1 - Publisher Copyright:
© 2020 American College of Physicians. All rights reserved.
PY - 2020/6/16
Y1 - 2020/6/16
N2 - Background: The DASH diet has been found to lower blood pressure (BP) and low-density lipoprotein cholesterol levels. Objective: To compare diets rich in fruits and vegetables with a typical American diet in their effects on cardiovascular injury in middle-aged adults without known preexisting cardiovascular disease (CVD). Design: Observational study based on a 3-group, parallel-design, randomized trial conducted in the United States from 1994 to 1996. (ClinicalTrials.gov: NCT00000544) Setting: 3 of the 4 original clinical trial centers. Participants: 326 of the original 459 trial participants with available stored specimens. Intervention: Participants were randomly assigned to 8 weeks of monitored feeding with a control diet typical of what many Americans eat; a diet rich in fruits and vegetables but otherwise similar to the control diet; or the DASH diet, which is rich in fruits, vegetables, low-fat dairy, and fiber and has low levels of saturated fat and cholesterol. Weight was kept constant throughout feeding. Measurements: Biomarkers collected at baseline and 8 weeks: high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro–B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP). Results: The mean age of participants was 45.2 years, 48% were women, 49% were black, and mean baseline BP was 131/85 mm Hg. Compared with the control diet, the fruit-and-vegetable diet reduced hs-cTnI levels by 0.5 ng/L (95% CI, -0.9 to -0.2 ng/L) and NT-proBNP levels by 0.3 pg/mL (CI,-0.5 to -0.1 pg/mL). Compared with the control diet, the DASH diet reduced hs-cTnI levels by 0.5 ng/L (CI, -0.9 to -0.1 ng/L) and NT-proBNP levels by 0.3 pg/mL (CI, -0.5 to -0.04 pg/mL). Levels of hs-CRP did not differ among diets. None of the markers differed between the fruit-and-vegetable and DASH diets. Limitation: Short duration, missing specimens, and an inability to isolate the effects of specific foods or micronutrients. Conclusion: Diets rich in fruits and vegetables given over 8 weeks were associated with lower levels of markers for subclinical cardiac damage and strain in adults without preexisting CVD.
AB - Background: The DASH diet has been found to lower blood pressure (BP) and low-density lipoprotein cholesterol levels. Objective: To compare diets rich in fruits and vegetables with a typical American diet in their effects on cardiovascular injury in middle-aged adults without known preexisting cardiovascular disease (CVD). Design: Observational study based on a 3-group, parallel-design, randomized trial conducted in the United States from 1994 to 1996. (ClinicalTrials.gov: NCT00000544) Setting: 3 of the 4 original clinical trial centers. Participants: 326 of the original 459 trial participants with available stored specimens. Intervention: Participants were randomly assigned to 8 weeks of monitored feeding with a control diet typical of what many Americans eat; a diet rich in fruits and vegetables but otherwise similar to the control diet; or the DASH diet, which is rich in fruits, vegetables, low-fat dairy, and fiber and has low levels of saturated fat and cholesterol. Weight was kept constant throughout feeding. Measurements: Biomarkers collected at baseline and 8 weeks: high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro–B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP). Results: The mean age of participants was 45.2 years, 48% were women, 49% were black, and mean baseline BP was 131/85 mm Hg. Compared with the control diet, the fruit-and-vegetable diet reduced hs-cTnI levels by 0.5 ng/L (95% CI, -0.9 to -0.2 ng/L) and NT-proBNP levels by 0.3 pg/mL (CI,-0.5 to -0.1 pg/mL). Compared with the control diet, the DASH diet reduced hs-cTnI levels by 0.5 ng/L (CI, -0.9 to -0.1 ng/L) and NT-proBNP levels by 0.3 pg/mL (CI, -0.5 to -0.04 pg/mL). Levels of hs-CRP did not differ among diets. None of the markers differed between the fruit-and-vegetable and DASH diets. Limitation: Short duration, missing specimens, and an inability to isolate the effects of specific foods or micronutrients. Conclusion: Diets rich in fruits and vegetables given over 8 weeks were associated with lower levels of markers for subclinical cardiac damage and strain in adults without preexisting CVD.
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U2 - 10.7326/M20-0336
DO - 10.7326/M20-0336
M3 - Article
C2 - 32423348
AN - SCOPUS:85086524821
SN - 0003-4819
VL - 172
SP - 786
EP - 794
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 12
ER -