TY - JOUR
T1 - Associations between dietary intake of B-vitamins and psychological disorders among Iranian women
T2 - A cross-sectional study
AU - Mozaffari, Hadis
AU - Darooghegi Mofrad, Manije
AU - Surkan, Pamela J.
AU - Askari, Mohammadreza
AU - Azadbakht, Leila
N1 - Funding Information:
Acknowledgements: The authors would like to thank the participants for taking part in this study. Financial support: This study was supported by Tehran University of Medical Sciences (grant and ethics number: 98-01-161-42024). Conflict of interest: The authors declare that they have no conflict of interest. Authorship: L.A. and H.M. designed the study. H.M., M.D.M. and M.A. contributed in statistical analysis, data interpretation and manuscript drafting. P.J.S. reviewed and edited the manuscript. The final version of manuscript for submission was approved by all authors. Ethics of human subject participation: The present study was conducted in accordance with the Helsinki Declaration, and all procedures involving human subjects were approved by the ethics committee of Tehran University of Medical Sciences. All the participants gave their permission for inclusion by signing an informed consent.
Publisher Copyright:
© 2021 Cambridge University Press. All rights reserved.
PY - 2021/5
Y1 - 2021/5
N2 - Objective: B-vitamins affect brain function through multiple pathways. Given limited evidence on the relationship between dietary intake of these vitamins and psychological disorders, we examined dietary intake of vitamin B6-9-12 in relation to psychological disorders among Iranian women. Design: Cross-sectional study. Dietary intake was assessed using a valid and reliable FFQ. To assess psychological disorders, we used a version of the Depression Anxiety Stress Scale-21 validated in Iran. Setting: Ten public health centres in southern Tehran, Iran. Participants: A total of 447 female participants aged 20-50 years. Results: The median values of vitamin B6 (pyridoxine), B9 (folate) and B12 (cobalamin) were 1·30 mg/d, 313·89 g/d and 3·99 g/d, respectively. After adjustment for potential confounders, dietary vitamin B6 intake was associated with lower odds of depression (OR: 0·54; 95 % CI: 0·31, 0·95; P trend: 0·03). However, there was a positive association between dietary vitamin B12 intake with the odds of depression (OR: 2·05; 95 % CI: 1·17, 3·60; P trend: 0·01) and psychological distress (OR: 2·00; 95 % CI: 1·17, 3·41; P trend: 0·01). No association was found between vitamin B9 with any psychological disorders. Conclusions: Women with higher dietary intakes of vitamin B6 had lower likelihood of depression. However, women with higher dietary intake of vitamin B12 had higher odds of depression and psychological distress. Future prospective studies in different populations are needed to clarify whether B-vitamin deficiency is a cause or consequence of psychological disorders.
AB - Objective: B-vitamins affect brain function through multiple pathways. Given limited evidence on the relationship between dietary intake of these vitamins and psychological disorders, we examined dietary intake of vitamin B6-9-12 in relation to psychological disorders among Iranian women. Design: Cross-sectional study. Dietary intake was assessed using a valid and reliable FFQ. To assess psychological disorders, we used a version of the Depression Anxiety Stress Scale-21 validated in Iran. Setting: Ten public health centres in southern Tehran, Iran. Participants: A total of 447 female participants aged 20-50 years. Results: The median values of vitamin B6 (pyridoxine), B9 (folate) and B12 (cobalamin) were 1·30 mg/d, 313·89 g/d and 3·99 g/d, respectively. After adjustment for potential confounders, dietary vitamin B6 intake was associated with lower odds of depression (OR: 0·54; 95 % CI: 0·31, 0·95; P trend: 0·03). However, there was a positive association between dietary vitamin B12 intake with the odds of depression (OR: 2·05; 95 % CI: 1·17, 3·60; P trend: 0·01) and psychological distress (OR: 2·00; 95 % CI: 1·17, 3·41; P trend: 0·01). No association was found between vitamin B9 with any psychological disorders. Conclusions: Women with higher dietary intakes of vitamin B6 had lower likelihood of depression. However, women with higher dietary intake of vitamin B12 had higher odds of depression and psychological distress. Future prospective studies in different populations are needed to clarify whether B-vitamin deficiency is a cause or consequence of psychological disorders.
KW - Cobalamin
KW - Folate
KW - Psychological disorder
KW - Pyridoxine
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UR - http://www.scopus.com/inward/citedby.url?scp=85092612814&partnerID=8YFLogxK
U2 - 10.1017/S1368980020002943
DO - 10.1017/S1368980020002943
M3 - Article
C2 - 32933593
AN - SCOPUS:85092612814
SN - 1368-9800
VL - 24
SP - 1787
EP - 1797
JO - Public health nutrition
JF - Public health nutrition
IS - 7
ER -