Associations between dietary insulin load with cardiovascular risk factors and inflammatory parameters in elderly men: A cross-sectional study

Hadis Mozaffari, Nazli Namazi, Bagher Larijani, Pamela J. Surkan, Leila Azadbakht

Research output: Contribution to journalArticlepeer-review

Abstract

Given the limited research on dietary insulin load (DIL), we examined DIL in relation to cardiovascular risk factors and inflammatory biomarkers in elderly men. For the present cross-sectional study, we recruited 357 elderly men. Dietary intake was assessed using FFQ. DIL was estimated by multiplying the insulin index of each food by its energy content and frequency of consumption and then summing the final value of all food items. After adjustment for covariates, a significant positive association was observed between high DIL with fasting blood sugar (FBS) levels (OR: 7·52; 95 % CI 3·38, 16·75; P=0·0001) and high-sensitive C-reactive protein (hs-CRP) (OR: 3·03; 95 % CI 1·54, 5·94; P=0·001). However, there was no association between high DIL and BMI (OR: 1·43; 95 % CI 0·75, 2·75; P=0·27), serum TAG level (OR: 0·82; 95 % CI 0·26, 2·59; P=0·73), HDL-cholesterol (OR: 2·03; 95 % CI 0·79, 5·23; P=0·13) and fibrinogen (OR: 1·57; 95 % CI 0·80, 3·06; P=0·18). Overall, elderly men with high DIL had higher FBS and hs-CRP levels than those with low DIL. Future studies are needed to clarify the association between DIL and other cardiovascular risk factors in both men and women.

Original languageEnglish (US)
Pages (from-to)773-781
Number of pages9
JournalBritish Journal of Nutrition
Volume121
Issue number7
DOIs
StatePublished - Apr 14 2019

Keywords

  • Dietary insulin load: Cardiovascular risks: Inflammation: Elderly

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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