TY - JOUR
T1 - Associations between dietary insulin load with cardiovascular risk factors and inflammatory parameters in elderly men
T2 - A cross-sectional study
AU - Mozaffari, Hadis
AU - Namazi, Nazli
AU - Larijani, Bagher
AU - Surkan, Pamela J.
AU - Azadbakht, Leila
N1 - Funding Information:
The authors thank the subjects who participated in the study. This study was funded by the National Institute for Medical Research Development (grant no. 965430). The National Institute for Medical Research had no role in the design, analysis or writing of this article. H. M., N. N. and L. A. designed the study. H. M., N. N., B. L., P. J. S. and L. A. contributed to the statistical analysis, interpretation of the data and to the drafting of the manuscript. The final version of the manuscript was approved by all authors before submission. The authors declare that there are no conflicts of interest.
Publisher Copyright:
© The Authors 2019.
PY - 2019/4/14
Y1 - 2019/4/14
N2 - Given the limited research on dietary insulin load (DIL), we examined DIL in relation to cardiovascular risk factors and inflammatory biomarkers in elderly men. For the present cross-sectional study, we recruited 357 elderly men. Dietary intake was assessed using FFQ. DIL was estimated by multiplying the insulin index of each food by its energy content and frequency of consumption and then summing the final value of all food items. After adjustment for covariates, a significant positive association was observed between high DIL with fasting blood sugar (FBS) levels (OR: 7·52; 95 % CI 3·38, 16·75; P=0·0001) and high-sensitive C-reactive protein (hs-CRP) (OR: 3·03; 95 % CI 1·54, 5·94; P=0·001). However, there was no association between high DIL and BMI (OR: 1·43; 95 % CI 0·75, 2·75; P=0·27), serum TAG level (OR: 0·82; 95 % CI 0·26, 2·59; P=0·73), HDL-cholesterol (OR: 2·03; 95 % CI 0·79, 5·23; P=0·13) and fibrinogen (OR: 1·57; 95 % CI 0·80, 3·06; P=0·18). Overall, elderly men with high DIL had higher FBS and hs-CRP levels than those with low DIL. Future studies are needed to clarify the association between DIL and other cardiovascular risk factors in both men and women.
AB - Given the limited research on dietary insulin load (DIL), we examined DIL in relation to cardiovascular risk factors and inflammatory biomarkers in elderly men. For the present cross-sectional study, we recruited 357 elderly men. Dietary intake was assessed using FFQ. DIL was estimated by multiplying the insulin index of each food by its energy content and frequency of consumption and then summing the final value of all food items. After adjustment for covariates, a significant positive association was observed between high DIL with fasting blood sugar (FBS) levels (OR: 7·52; 95 % CI 3·38, 16·75; P=0·0001) and high-sensitive C-reactive protein (hs-CRP) (OR: 3·03; 95 % CI 1·54, 5·94; P=0·001). However, there was no association between high DIL and BMI (OR: 1·43; 95 % CI 0·75, 2·75; P=0·27), serum TAG level (OR: 0·82; 95 % CI 0·26, 2·59; P=0·73), HDL-cholesterol (OR: 2·03; 95 % CI 0·79, 5·23; P=0·13) and fibrinogen (OR: 1·57; 95 % CI 0·80, 3·06; P=0·18). Overall, elderly men with high DIL had higher FBS and hs-CRP levels than those with low DIL. Future studies are needed to clarify the association between DIL and other cardiovascular risk factors in both men and women.
KW - Dietary insulin load: Cardiovascular risks: Inflammation: Elderly
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U2 - 10.1017/S0007114518003872
DO - 10.1017/S0007114518003872
M3 - Article
C2 - 30670105
AN - SCOPUS:85060383382
SN - 0007-1145
VL - 121
SP - 773
EP - 781
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 7
ER -