Associations between CYP19A1 polymorphisms, Native American ancestry, and breast cancer risk and mortality: the Breast Cancer Health Disparities Study

Stephanie D. Boone, Kathy B. Baumgartner, Richard N. Baumgartner, Avonne E. Connor, Christina M. Pinkston, Shesh N. Rai, Elizabeth C. Riley, Lisa M. Hines, Anna R. Giuliano, Esther M. John, Mariana C. Stern, Gabriela Torres-Mejía, Roger K. Wolff, Martha L. Slattery

Research output: Contribution to journalArticlepeer-review

Abstract

The cytochrome p450 family 19 gene (CYP19A1) encodes for aromatase, which catalyzes the final step in estrogen biosynthesis and conversion of androgens to estrogens. Genetic variation in CYP19A1 is linked to higher circulating estrogen levels and increased aromatase expression. Using data from the Breast Cancer Health Disparities Study, a consortium of three population-based case–control studies in the United States (n = 3,030 non-Hispanic Whites; n = 2,893 Hispanic/Native Americans (H/NA) and Mexico (n = 1,810), we examined influence of 25 CYP19A1 tagging single-nucleotide polymorphisms (SNPs) on breast cancer risk and mortality, considering NA ancestry. Odds ratios (ORs) and 95 % confidence intervals (CIs) and hazard ratios estimated breast cancer risk and mortality. After multiple comparison adjustment, none of the SNPs were significantly associated with breast cancer risk or mortality. Two SNPs remained significantly associated with increased breast cancer risk in women of moderate to high NA ancestry (≥29 %): rs700518, ORGG1.36, 95 % CI 1.11–1.67 and rs11856927, ORGG1.35, 95 % CI 1.05–1.72. A significant interaction was observed for rs2470144 and menopausal status (padj = 0.03); risk was increased in postmenopausal (ORAA1.22, 95 % CI 1.05–1.14), but not premenopausal (ORAA0.78, 95 % CI 0.64–0.95) women. The absence of an overall association with CYP19A1 and breast cancer risk is similar to previous literature. However, this analysis provides support that variation in CYP19A1 may influence breast cancer risk differently in women with moderate to high NA ancestry. Additional research is warranted to investigate the how variation in an estrogen-regulating gene contributes to racial/ethnic disparities in breast cancer.

Original languageEnglish (US)
Pages (from-to)1461-1471
Number of pages11
JournalCancer Causes and Control
Volume25
Issue number11
DOIs
StatePublished - Oct 31 2014

Keywords

  • Breast cancer mortality
  • Breast cancer risk
  • CYP19A1 polymorphisms
  • Native American ancestry

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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