Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults: The cardiovascular health study

Cara L. Carty, Mary Cushman, Daniel Jones, Leslie A. Lange, Lucia A. Hindorff, Kenneth Rice, Nancy S. Jenny, J. Peter Durda, Jeremy D Walston, Christopher S. Carlson, Debbie Nickerson, Russell P. Tracy, Alex P. Reiner

Research output: Contribution to journalArticle

Abstract

Elevated plasma fibrinogen is a risk factor for cardiovascular disease (CVD), but associations between fibrinogen single nucleotide polymorphisms (SNPs) and disease risk are inconsistent. We investigated whether common (≥ 5% minor allele frequency) variation in the fibrinogen genes (FGA, FGB, FGG) is associated with fibrinogen concentration, carotid artery intima-medial thickness (IMT) and risk of incident myocardial infarction (MI), ischemic stroke and CVD mortality in European- (EA) and African-descent (AA) adults (≥ 65 years) from the Cardiovascular Health Study. TagSNPs were genotyped in 3,969 EA and 719 AA free of MI or stroke at baseline. Race-specific models included multiple testing correction and adjustment for sex, age and site. Among EA,minor alleles of FGA3807, FGB1437 and FGG902 were associated with higher fibrinogen levels; whereas FGA251, FGA2224, FGA6534 and FGG10034 were associated with lower levels, p

Original languageEnglish (US)
Pages (from-to)388-395
Number of pages8
JournalThrombosis and Haemostasis
Volume99
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Fibrinogen
Cardiovascular Diseases
Health
Genes
Stroke
Myocardial Infarction
Carotid Arteries
Gene Frequency
Single Nucleotide Polymorphism
Alleles
Mortality

Keywords

  • Atherosclerosis
  • Epidemiological studies
  • Fibrinogen
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Hematology

Cite this

Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults : The cardiovascular health study. / Carty, Cara L.; Cushman, Mary; Jones, Daniel; Lange, Leslie A.; Hindorff, Lucia A.; Rice, Kenneth; Jenny, Nancy S.; Durda, J. Peter; Walston, Jeremy D; Carlson, Christopher S.; Nickerson, Debbie; Tracy, Russell P.; Reiner, Alex P.

In: Thrombosis and Haemostasis, Vol. 99, No. 2, 02.2008, p. 388-395.

Research output: Contribution to journalArticle

Carty, CL, Cushman, M, Jones, D, Lange, LA, Hindorff, LA, Rice, K, Jenny, NS, Durda, JP, Walston, JD, Carlson, CS, Nickerson, D, Tracy, RP & Reiner, AP 2008, 'Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults: The cardiovascular health study', Thrombosis and Haemostasis, vol. 99, no. 2, pp. 388-395. https://doi.org/10.1160/TH07-08-0523
Carty, Cara L. ; Cushman, Mary ; Jones, Daniel ; Lange, Leslie A. ; Hindorff, Lucia A. ; Rice, Kenneth ; Jenny, Nancy S. ; Durda, J. Peter ; Walston, Jeremy D ; Carlson, Christopher S. ; Nickerson, Debbie ; Tracy, Russell P. ; Reiner, Alex P. / Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults : The cardiovascular health study. In: Thrombosis and Haemostasis. 2008 ; Vol. 99, No. 2. pp. 388-395.
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