Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study

Zhiyu Xia, Kathy B. Baumgartner, Richard N. Baumgartner, Stephanie D. Boone, Lisa M. Hines, Esther M. John, Roger Wolff, Martha L. Slattery, Avonne Connor

Research output: Contribution to journalArticle

Abstract

Purpose: ALDH1A1, one of the main isotopes of aldehyde dehydrogenase-1 is involved in the differentiation and protection of normal hematopoietic stem cells and functions in alcohol sensitivity and dependence. We evaluated the associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white (NHW) breast cancer (BC) cases from the Breast Cancer Health Disparities Study. Methods: Nine SNPs in ALDH1A1 were evaluated in 920 Hispanic and 1372 NHW women diagnosed with incident invasive BC. Adjusted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Models were stratified by Native American (NA) ancestry and alcohol consumption. Results: A total of 443 deaths occurred over a median follow-up time of 11 years. After adjusting all results for multiple comparisons, rs7027604 was significantly associated with all-cause mortality (HRAA = 1.40; 95% CI 1.13–1.73, Padj = 0.018). The rs1424482 CC genotype (HRCC = 1.69; 95% CI 1.20–2.37, Padj = 0.027) and the rs7027604 AA genotype (HRAA = 1.65; 95% CI 1.21–2.26, Padj = 0.018) were positively associated with non-BC mortality. Among long-term light drinkers, rs1888202 was associated with decreased all-cause mortality (HRCG/GG = 0.36; 95% CI 0.20–0.64), while associations were not significant among non-drinkers or moderate/heavy drinkers (Pinteration = 0.218). The increased risk of all-cause mortality associated with rs63319 was limited to women with low NA ancestry (HRAA = 1.53; 95% CI 1.19–1.97). Conclusions: Multiple SNPs in ALDH1A1 were associated with increased risk of mortality after BC. Future BC studies examining the relationship between ALDH1A1 and mortality should consider the modifying effects of alcohol consumption and NA ancestry.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - Nov 30 2017

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Hispanic Americans
Alcohol Drinking
Breast Neoplasms
Confidence Intervals
Mortality
Health
North American Indians
Single Nucleotide Polymorphism
Genotype
Hematopoietic Stem Cells
Proportional Hazards Models
Isotopes
Alcoholism
Neoplasms

Keywords

  • Alcohol consumption
  • ALDH1A1
  • Breast cancer
  • Hispanics
  • Mortality

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer : the Breast Cancer Health Disparities Study. / Xia, Zhiyu; Baumgartner, Kathy B.; Baumgartner, Richard N.; Boone, Stephanie D.; Hines, Lisa M.; John, Esther M.; Wolff, Roger; Slattery, Martha L.; Connor, Avonne.

In: Breast Cancer Research and Treatment, 30.11.2017, p. 1-13.

Research output: Contribution to journalArticle

Xia, Zhiyu ; Baumgartner, Kathy B. ; Baumgartner, Richard N. ; Boone, Stephanie D. ; Hines, Lisa M. ; John, Esther M. ; Wolff, Roger ; Slattery, Martha L. ; Connor, Avonne. / Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer : the Breast Cancer Health Disparities Study. In: Breast Cancer Research and Treatment. 2017 ; pp. 1-13.
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abstract = "Purpose: ALDH1A1, one of the main isotopes of aldehyde dehydrogenase-1 is involved in the differentiation and protection of normal hematopoietic stem cells and functions in alcohol sensitivity and dependence. We evaluated the associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white (NHW) breast cancer (BC) cases from the Breast Cancer Health Disparities Study. Methods: Nine SNPs in ALDH1A1 were evaluated in 920 Hispanic and 1372 NHW women diagnosed with incident invasive BC. Adjusted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95{\%} confidence intervals (CIs). Models were stratified by Native American (NA) ancestry and alcohol consumption. Results: A total of 443 deaths occurred over a median follow-up time of 11 years. After adjusting all results for multiple comparisons, rs7027604 was significantly associated with all-cause mortality (HRAA = 1.40; 95{\%} CI 1.13–1.73, Padj = 0.018). The rs1424482 CC genotype (HRCC = 1.69; 95{\%} CI 1.20–2.37, Padj = 0.027) and the rs7027604 AA genotype (HRAA = 1.65; 95{\%} CI 1.21–2.26, Padj = 0.018) were positively associated with non-BC mortality. Among long-term light drinkers, rs1888202 was associated with decreased all-cause mortality (HRCG/GG = 0.36; 95{\%} CI 0.20–0.64), while associations were not significant among non-drinkers or moderate/heavy drinkers (Pinteration = 0.218). The increased risk of all-cause mortality associated with rs63319 was limited to women with low NA ancestry (HRAA = 1.53; 95{\%} CI 1.19–1.97). Conclusions: Multiple SNPs in ALDH1A1 were associated with increased risk of mortality after BC. Future BC studies examining the relationship between ALDH1A1 and mortality should consider the modifying effects of alcohol consumption and NA ancestry.",
keywords = "Alcohol consumption, ALDH1A1, Breast cancer, Hispanics, Mortality",
author = "Zhiyu Xia and Baumgartner, {Kathy B.} and Baumgartner, {Richard N.} and Boone, {Stephanie D.} and Hines, {Lisa M.} and John, {Esther M.} and Roger Wolff and Slattery, {Martha L.} and Avonne Connor",
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T1 - Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer

T2 - the Breast Cancer Health Disparities Study

AU - Xia, Zhiyu

AU - Baumgartner, Kathy B.

AU - Baumgartner, Richard N.

AU - Boone, Stephanie D.

AU - Hines, Lisa M.

AU - John, Esther M.

AU - Wolff, Roger

AU - Slattery, Martha L.

AU - Connor, Avonne

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Purpose: ALDH1A1, one of the main isotopes of aldehyde dehydrogenase-1 is involved in the differentiation and protection of normal hematopoietic stem cells and functions in alcohol sensitivity and dependence. We evaluated the associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white (NHW) breast cancer (BC) cases from the Breast Cancer Health Disparities Study. Methods: Nine SNPs in ALDH1A1 were evaluated in 920 Hispanic and 1372 NHW women diagnosed with incident invasive BC. Adjusted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Models were stratified by Native American (NA) ancestry and alcohol consumption. Results: A total of 443 deaths occurred over a median follow-up time of 11 years. After adjusting all results for multiple comparisons, rs7027604 was significantly associated with all-cause mortality (HRAA = 1.40; 95% CI 1.13–1.73, Padj = 0.018). The rs1424482 CC genotype (HRCC = 1.69; 95% CI 1.20–2.37, Padj = 0.027) and the rs7027604 AA genotype (HRAA = 1.65; 95% CI 1.21–2.26, Padj = 0.018) were positively associated with non-BC mortality. Among long-term light drinkers, rs1888202 was associated with decreased all-cause mortality (HRCG/GG = 0.36; 95% CI 0.20–0.64), while associations were not significant among non-drinkers or moderate/heavy drinkers (Pinteration = 0.218). The increased risk of all-cause mortality associated with rs63319 was limited to women with low NA ancestry (HRAA = 1.53; 95% CI 1.19–1.97). Conclusions: Multiple SNPs in ALDH1A1 were associated with increased risk of mortality after BC. Future BC studies examining the relationship between ALDH1A1 and mortality should consider the modifying effects of alcohol consumption and NA ancestry.

AB - Purpose: ALDH1A1, one of the main isotopes of aldehyde dehydrogenase-1 is involved in the differentiation and protection of normal hematopoietic stem cells and functions in alcohol sensitivity and dependence. We evaluated the associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white (NHW) breast cancer (BC) cases from the Breast Cancer Health Disparities Study. Methods: Nine SNPs in ALDH1A1 were evaluated in 920 Hispanic and 1372 NHW women diagnosed with incident invasive BC. Adjusted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Models were stratified by Native American (NA) ancestry and alcohol consumption. Results: A total of 443 deaths occurred over a median follow-up time of 11 years. After adjusting all results for multiple comparisons, rs7027604 was significantly associated with all-cause mortality (HRAA = 1.40; 95% CI 1.13–1.73, Padj = 0.018). The rs1424482 CC genotype (HRCC = 1.69; 95% CI 1.20–2.37, Padj = 0.027) and the rs7027604 AA genotype (HRAA = 1.65; 95% CI 1.21–2.26, Padj = 0.018) were positively associated with non-BC mortality. Among long-term light drinkers, rs1888202 was associated with decreased all-cause mortality (HRCG/GG = 0.36; 95% CI 0.20–0.64), while associations were not significant among non-drinkers or moderate/heavy drinkers (Pinteration = 0.218). The increased risk of all-cause mortality associated with rs63319 was limited to women with low NA ancestry (HRAA = 1.53; 95% CI 1.19–1.97). Conclusions: Multiple SNPs in ALDH1A1 were associated with increased risk of mortality after BC. Future BC studies examining the relationship between ALDH1A1 and mortality should consider the modifying effects of alcohol consumption and NA ancestry.

KW - Alcohol consumption

KW - ALDH1A1

KW - Breast cancer

KW - Hispanics

KW - Mortality

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