TY - JOUR
T1 - Associations between β-peripapillary atrophy and reticular pseudodrusen in early age-related macular degeneration
AU - Garg, Aakriti
AU - Blumberg, Dana M.
AU - Al-Aswad, Lama A.
AU - Oll, Maris
AU - Yzer, Suzanne
AU - Forbes, Max
AU - Allikmets, Rando L.
AU - Bearelly, Srilaxmi
N1 - Funding Information:
The authors thank Hamed B. Bazargan Lari, MD, for his help in image grading. Presented at The American Academy of Ophthalmology Annual Meeting, November, 2013: Poster Number PO446. Supported by a grant from the Doris Duke Charitable Foundation to Columbia University (AG), a National Eye Institute Travel Grant to the 2014 ARVO Annual Meeting (AG), National Eye Institute/ National Institutes of Health Grants EY013435 and EY019007 (Core Support for Vision Research), Robert L. Burch III Fund, Columbia University (SB), and the New York Community Trust– Fredrick J. and Theresa Dow Wallace Fund. The funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2017 The Authors.
PY - 2017/5
Y1 - 2017/5
N2 - PURPOSE. Choroidal thinning has been associated with reticular pseudodrusen (RPD) and bperipapillary atrophy (β-PPA), which have been linked to normal-tension glaucoma (NTG). This analysis sought to determine whether RPD are independently associated with β-PPA in early AMD patients. Secondary outcomes included the association of RPD and preexisting diagnosis of glaucoma, cup-to-disc ratio (CDR), subfoveal choroidal thickness (SFCT), and IOP. METHODS. This prospective cross-sectional study examined 78 age-and sex-matched early AMD patients: 43 RPD patients (63 eyes) and 35 non-RPD patients (64 eyes). Exclusion criteria included advanced AMD, high myopia, and vitreoretinal conditions/surgery. RPD and non-RPD groups were identified by confocal scanning laser ophthalmoscopy. β-PPA as well as CDR were graded on digital, nonstereoscopic fundus photos. SFCT was measured on spectraldomain optical coherence tomography for 69 patients (35 RPD and 34 non-RPD). IOP and glaucoma diagnosis were extracted from charts. RESULTS. β-PPA had a greater prevalence in RPD than non-RPD (44% vs. 19%, P = 0.002); however, this relationship was not significant when SFCT was added to the model (P = 0.150). A preexisting diagnosis of glaucoma (P = 0.156), CDR (P = 0.176), and IOP (P = 0.98) was not different between groups. CONCLUSIONS. RPD in early AMD are associated with presence of β-PPA, but choroidal thickness is a confounder in this relationship. Because β-PPA is a common finding in NTG, focusing on a potential shared pathway between RPD and NTG could improve the understanding of pathophysiology and expand therapies for each condition.
AB - PURPOSE. Choroidal thinning has been associated with reticular pseudodrusen (RPD) and bperipapillary atrophy (β-PPA), which have been linked to normal-tension glaucoma (NTG). This analysis sought to determine whether RPD are independently associated with β-PPA in early AMD patients. Secondary outcomes included the association of RPD and preexisting diagnosis of glaucoma, cup-to-disc ratio (CDR), subfoveal choroidal thickness (SFCT), and IOP. METHODS. This prospective cross-sectional study examined 78 age-and sex-matched early AMD patients: 43 RPD patients (63 eyes) and 35 non-RPD patients (64 eyes). Exclusion criteria included advanced AMD, high myopia, and vitreoretinal conditions/surgery. RPD and non-RPD groups were identified by confocal scanning laser ophthalmoscopy. β-PPA as well as CDR were graded on digital, nonstereoscopic fundus photos. SFCT was measured on spectraldomain optical coherence tomography for 69 patients (35 RPD and 34 non-RPD). IOP and glaucoma diagnosis were extracted from charts. RESULTS. β-PPA had a greater prevalence in RPD than non-RPD (44% vs. 19%, P = 0.002); however, this relationship was not significant when SFCT was added to the model (P = 0.150). A preexisting diagnosis of glaucoma (P = 0.156), CDR (P = 0.176), and IOP (P = 0.98) was not different between groups. CONCLUSIONS. RPD in early AMD are associated with presence of β-PPA, but choroidal thickness is a confounder in this relationship. Because β-PPA is a common finding in NTG, focusing on a potential shared pathway between RPD and NTG could improve the understanding of pathophysiology and expand therapies for each condition.
KW - Age-related macular degeneration
KW - Beta-peripapillary atrophy
KW - Choroidal thinning
KW - Normal-tension glaucoma
KW - Reticular pseudodrusen
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U2 - 10.1167/iovs.16-20343
DO - 10.1167/iovs.16-20343
M3 - Article
C2 - 28564702
AN - SCOPUS:85024385917
SN - 0146-0404
VL - 58
SP - 2810
EP - 2815
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 5
ER -