Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial

Kevin Frick, Lea T. Drye, John H. Kempen, James P. Dunn, Gary N. Holland, Paul Latkany, Narsing A. Rao, H. Nida Sen, Elizabeth Sugar, Jennifer Thorne, Robert C. Wang, Janet Teresa Holbrook

Research output: Contribution to journalArticle

Abstract

PURPOSE. To evaluate the associations between visual acuity and self-reported visual function; visual acuity and ealthrelated quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL in patients with uveitis. METHODS. Best-corrected visual acuity, vision-related functioning as assessed by the NEI VFQ-25, and health-related QoL as assessed by the SF-36 and EuroQoL EQ-5D questionnaires were obtained at enrollment in a clinical trial of uveitis treatments. Multivariate regression and Spearman correlations were used to evaluate associations between visual acuity, vision-related function, and health-related QoL. RESULTS. Among the 255 patients, median visual acuity in the better-seeing eyes was 20/25, the vision-related function score indicated impairment (median, 60), and health-related QoL scores were within the normal population range. Better visual acuity was predictive of higher visual function scores (P ≤ 0.001), a higher SF-36 physical component score, and a higher EQ-5D health utility score (P <0.001). The vision-specific function score was predictive of all general health-related QoL (P <0.001). The correlations between visual function score and general quality of life measures were moderate (p = 0.29-0.52). CONCLUSIONS. The vision-related function score correlated positively with visual acuity and moderately positively with general QoL measures. Cost-utility analyses relying on changes in generic healthy utility measures will be more likely to detect changes when there are clinically meaningful changes in vision-related function, rather than when there are only changes in visual acuity.

Original languageEnglish (US)
Pages (from-to)1169-1176
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number3
DOIs
StatePublished - Mar 2012

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Uveitis
Visual Acuity
Steroids
Quality of Life
Therapeutics
Cost-Benefit Analysis
Reference Values
Clinical Trials
Health

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial. / Frick, Kevin; Drye, Lea T.; Kempen, John H.; Dunn, James P.; Holland, Gary N.; Latkany, Paul; Rao, Narsing A.; Nida Sen, H.; Sugar, Elizabeth; Thorne, Jennifer; Wang, Robert C.; Holbrook, Janet Teresa.

In: Investigative Ophthalmology and Visual Science, Vol. 53, No. 3, 03.2012, p. 1169-1176.

Research output: Contribution to journalArticle

Frick, Kevin ; Drye, Lea T. ; Kempen, John H. ; Dunn, James P. ; Holland, Gary N. ; Latkany, Paul ; Rao, Narsing A. ; Nida Sen, H. ; Sugar, Elizabeth ; Thorne, Jennifer ; Wang, Robert C. ; Holbrook, Janet Teresa. / Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial. In: Investigative Ophthalmology and Visual Science. 2012 ; Vol. 53, No. 3. pp. 1169-1176.
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abstract = "PURPOSE. To evaluate the associations between visual acuity and self-reported visual function; visual acuity and ealthrelated quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL in patients with uveitis. METHODS. Best-corrected visual acuity, vision-related functioning as assessed by the NEI VFQ-25, and health-related QoL as assessed by the SF-36 and EuroQoL EQ-5D questionnaires were obtained at enrollment in a clinical trial of uveitis treatments. Multivariate regression and Spearman correlations were used to evaluate associations between visual acuity, vision-related function, and health-related QoL. RESULTS. Among the 255 patients, median visual acuity in the better-seeing eyes was 20/25, the vision-related function score indicated impairment (median, 60), and health-related QoL scores were within the normal population range. Better visual acuity was predictive of higher visual function scores (P ≤ 0.001), a higher SF-36 physical component score, and a higher EQ-5D health utility score (P <0.001). The vision-specific function score was predictive of all general health-related QoL (P <0.001). The correlations between visual function score and general quality of life measures were moderate (p = 0.29-0.52). CONCLUSIONS. The vision-related function score correlated positively with visual acuity and moderately positively with general QoL measures. Cost-utility analyses relying on changes in generic healthy utility measures will be more likely to detect changes when there are clinically meaningful changes in vision-related function, rather than when there are only changes in visual acuity.",
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T1 - Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial

AU - Frick, Kevin

AU - Drye, Lea T.

AU - Kempen, John H.

AU - Dunn, James P.

AU - Holland, Gary N.

AU - Latkany, Paul

AU - Rao, Narsing A.

AU - Nida Sen, H.

AU - Sugar, Elizabeth

AU - Thorne, Jennifer

AU - Wang, Robert C.

AU - Holbrook, Janet Teresa

PY - 2012/3

Y1 - 2012/3

N2 - PURPOSE. To evaluate the associations between visual acuity and self-reported visual function; visual acuity and ealthrelated quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL in patients with uveitis. METHODS. Best-corrected visual acuity, vision-related functioning as assessed by the NEI VFQ-25, and health-related QoL as assessed by the SF-36 and EuroQoL EQ-5D questionnaires were obtained at enrollment in a clinical trial of uveitis treatments. Multivariate regression and Spearman correlations were used to evaluate associations between visual acuity, vision-related function, and health-related QoL. RESULTS. Among the 255 patients, median visual acuity in the better-seeing eyes was 20/25, the vision-related function score indicated impairment (median, 60), and health-related QoL scores were within the normal population range. Better visual acuity was predictive of higher visual function scores (P ≤ 0.001), a higher SF-36 physical component score, and a higher EQ-5D health utility score (P <0.001). The vision-specific function score was predictive of all general health-related QoL (P <0.001). The correlations between visual function score and general quality of life measures were moderate (p = 0.29-0.52). CONCLUSIONS. The vision-related function score correlated positively with visual acuity and moderately positively with general QoL measures. Cost-utility analyses relying on changes in generic healthy utility measures will be more likely to detect changes when there are clinically meaningful changes in vision-related function, rather than when there are only changes in visual acuity.

AB - PURPOSE. To evaluate the associations between visual acuity and self-reported visual function; visual acuity and ealthrelated quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL in patients with uveitis. METHODS. Best-corrected visual acuity, vision-related functioning as assessed by the NEI VFQ-25, and health-related QoL as assessed by the SF-36 and EuroQoL EQ-5D questionnaires were obtained at enrollment in a clinical trial of uveitis treatments. Multivariate regression and Spearman correlations were used to evaluate associations between visual acuity, vision-related function, and health-related QoL. RESULTS. Among the 255 patients, median visual acuity in the better-seeing eyes was 20/25, the vision-related function score indicated impairment (median, 60), and health-related QoL scores were within the normal population range. Better visual acuity was predictive of higher visual function scores (P ≤ 0.001), a higher SF-36 physical component score, and a higher EQ-5D health utility score (P <0.001). The vision-specific function score was predictive of all general health-related QoL (P <0.001). The correlations between visual function score and general quality of life measures were moderate (p = 0.29-0.52). CONCLUSIONS. The vision-related function score correlated positively with visual acuity and moderately positively with general QoL measures. Cost-utility analyses relying on changes in generic healthy utility measures will be more likely to detect changes when there are clinically meaningful changes in vision-related function, rather than when there are only changes in visual acuity.

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