Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population

Xuan Zhang, Mamoru Tochigi, Jun Ohashi, Kazuhisa Maeda, Tadafumi Kato, Yuji Okazaki, Nobumasa Kato, Katsushi Tokunaga, Akira Sawa, Tsukasa Sasaki

Research output: Contribution to journalArticlepeer-review

Abstract

Disrupted-in-Schizophrenia-1 (DISC1), identified by cytogenetic approaches in a pedigree with familial psychosis, is considered a candidate susceptibility gene for schizophrenia in some populations. In the pedigree, the TRAX gene, located adjacent to DISC1 on the disrupted chromosome 1, may also contribute to the pathophysiology of the familial schizophrenia. We studied association of the DISC1 and TRAX genes with schizophrenia in 338 Japanese by analyzing 15 single nucleotide polymorphisms (SNPs), including 12 SNPs in DISC1 and three in TRAX, respectively. No significant difference was observed between the patients and controls in allelic frequencies or genotypic distributions of 15 SNPs. A weak trend for the association in genotypic distribution of one SNP in TRAX (major homo/hetero/minor homo: 0.324/0.431/0.245 vs. 0.293/0.526/0.181 for patients vs controls, p = 0.039 in the 2 × 3 comparison) turned out to be insignificant after Bonferroni correction. Haplotype analysis did not support the association between the patients and controls. The present study suggests that the DISC1/TRAX locus may not have a major role in Japanese schizophrenia.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalSchizophrenia Research
Volume79
Issue number2-3
DOIs
StatePublished - Nov 15 2005

Keywords

  • Case-control
  • DISC1
  • Genetic association
  • Schizophrenia
  • TRAX

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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