Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: Probable effects of family history of schizophrenia?

V. L. Nimgaonkar, X. R. Zhang, J. G. Caldwell, R. Ganguli, A. Chakravarti

Research output: Contribution to journalArticle

Abstract

Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).

Original languageEnglish (US)
Pages (from-to)214-217
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume48
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Dopamine D3 Receptors
Schizophrenia
Alleles
Genes
Diagnostic and Statistical Manual of Mental Disorders
Odds Ratio
Genotype

Keywords

  • case-control association
  • dopamine receptor gene
  • family history
  • schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Association study of schizophrenia with dopamine D3 receptor gene polymorphisms : Probable effects of family history of schizophrenia? / Nimgaonkar, V. L.; Zhang, X. R.; Caldwell, J. G.; Ganguli, R.; Chakravarti, A.

In: American Journal of Medical Genetics, Vol. 48, No. 4, 1993, p. 214-217.

Research output: Contribution to journalArticle

Nimgaonkar, V. L. ; Zhang, X. R. ; Caldwell, J. G. ; Ganguli, R. ; Chakravarti, A. / Association study of schizophrenia with dopamine D3 receptor gene polymorphisms : Probable effects of family history of schizophrenia?. In: American Journal of Medical Genetics. 1993 ; Vol. 48, No. 4. pp. 214-217.
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