Abstract
Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-217 |
| Number of pages | 4 |
| Journal | American journal of medical genetics |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 27 1993 |
Keywords
- case-control association
- dopamine receptor gene
- family history
- schizophrenia
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
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Nimgaonkar, V. L., Zhang, X. R., Caldwell, J. G., Ganguli, R., & Chakravarti, A. (1993). Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: Probable effects of family history of schizophrenia? American journal of medical genetics, 48(4), 214-217. https://doi.org/10.1002/ajmg.1320480408