Abstract
Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-217 |
| Number of pages | 4 |
| Journal | American Journal of Medical Genetics |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- case-control association
- dopamine receptor gene
- family history
- schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)
- Neuroscience(all)
- Neuropsychology and Physiological Psychology
Cite this
Association study of schizophrenia with dopamine D3 receptor gene polymorphisms : Probable effects of family history of schizophrenia? / Nimgaonkar, V. L.; Zhang, X. R.; Caldwell, J. G.; Ganguli, R.; Chakravarti, A.
In: American Journal of Medical Genetics, Vol. 48, No. 4, 1993, p. 214-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association study of schizophrenia with dopamine D3 receptor gene polymorphisms
T2 - Probable effects of family history of schizophrenia?
AU - Nimgaonkar, V. L.
AU - Zhang, X. R.
AU - Caldwell, J. G.
AU - Ganguli, R.
AU - Chakravarti, A.
PY - 1993
Y1 - 1993
N2 - Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).
AB - Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).
KW - case-control association
KW - dopamine receptor gene
KW - family history
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0027142626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027142626&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320480408
DO - 10.1002/ajmg.1320480408
M3 - Article
C2 - 8135304
AN - SCOPUS:0027142626
VL - 48
SP - 214
EP - 217
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 4
ER -