Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: Probable effects of family history of schizophrenia?

V. L. Nimgaonkar, X. R. Zhang, J. G. Caldwell, R. Ganguli, A. Chakravarti

Research output: Contribution to journalArticle

Abstract

Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).

Original languageEnglish (US)
Pages (from-to)214-217
Number of pages4
JournalAmerican journal of medical genetics
Volume48
Issue number4
DOIs
StatePublished - Dec 27 1993

Keywords

  • case-control association
  • dopamine receptor gene
  • family history
  • schizophrenia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: Probable effects of family history of schizophrenia?'. Together they form a unique fingerprint.

  • Cite this