Association study of schizophrenia and the IL-2 receptor β chain gene

V. L. Nimgaonkar, Z. W. Yang, X. R. Zhang, J. S. Brar, A. Chakravarti, R. Ganguli

Research output: Contribution to journalArticle

Abstract

A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2Rβ chain gene, were examined in both groups. No significant differences in IL- 2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2Rβ gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume60
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • IL-2 receptor
  • association
  • genetics
  • schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Nimgaonkar, V. L., Yang, Z. W., Zhang, X. R., Brar, J. S., Chakravarti, A., & Ganguli, R. (1995). Association study of schizophrenia and the IL-2 receptor β chain gene. American Journal of Medical Genetics - Neuropsychiatric Genetics, 60(5), 448-451. https://doi.org/10.1002/ajmg.1320600517