Association study of schizophrenia and the IL-2 receptor β chain gene

V. L. Nimgaonkar; Z. W. Yang; X. R. Zhang; J. S. Brar; A. Chakravarti; R. Ganguli

doi:10.1002/ajmg.1320600517

Association study of schizophrenia and the IL-2 receptor β chain gene

V. L. Nimgaonkar, Z. W. Yang, X. R. Zhang, J. S. Brar, A. Chakravarti, R. Ganguli

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2Rβ chain gene, were examined in both groups. No significant differences in IL- 2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2Rβ gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.

Original language	English (US)
Pages (from-to)	448-451
Number of pages	4
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	60
Issue number	5
DOIs	https://doi.org/10.1002/ajmg.1320600517
State	Published - 1995
Externally published	Yes

Keywords

IL-2 receptor
association
genetics
schizophrenia

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1002/ajmg.1320600517

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abstract = "A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2Rβ chain gene, were examined in both groups. No significant differences in IL- 2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2Rβ gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.",

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AU - Nimgaonkar, V. L.

AU - Yang, Z. W.

AU - Zhang, X. R.

AU - Brar, J. S.

AU - Chakravarti, A.

AU - Ganguli, R.

PY - 1995

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AB - A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2Rβ chain gene, were examined in both groups. No significant differences in IL- 2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2Rβ gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.

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Association study of schizophrenia and the IL-2 receptor β chain gene

Abstract

Keywords

ASJC Scopus subject areas

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