TY - JOUR
T1 - Association study of IL10, IL1β, and IL1RN and schizophrenia using tag SNPs from a comprehensive database
T2 - Suggestive association with rs16944 at IL1β
AU - Shirts, Brian H.
AU - Wood, Joel
AU - Yolken, Robert H.
AU - Nimgaonkar, Vishwajit L.
N1 - Funding Information:
The authors would like to thank Kodavali Chowdari for making his haplotype data available, and Bernie Devlin and Michael Talkowski for advice on study design and analysis. This research was supported in part by grants from the Stanley Medical Research Institute (VLN) and the NIH (MH074265 to BHS and MH56242 to VLN).
PY - 2006/12
Y1 - 2006/12
N2 - Genetic association studies of several candidate cytokine genes have been motivated by evidence of immune dysfunction among patients with schizophrenia. Intriguing but inconsistent associations have been reported with polymorphisms of three positional candidate genes, namely IL1β, IL1RN, and IL10. We used comprehensive sequencing data from the Seattle SNPs database to select tag SNPs that represent all common polymorphisms in the Caucasian population at these loci. Associations with 28 tag SNPs were evaluated in 478 cases and 501 unscreened control individuals, while accounting for population sub-structure using the genomic control method. The samples were also stratified by gender, diagnostic category, and exposure to infectious agents. Significant association was not detected after correcting for multiple comparisons. However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1β - 511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n = 819 cases, 1292 controls; p = 0.0013, OR = 1.24, 95% CI 1.09, 1.41).
AB - Genetic association studies of several candidate cytokine genes have been motivated by evidence of immune dysfunction among patients with schizophrenia. Intriguing but inconsistent associations have been reported with polymorphisms of three positional candidate genes, namely IL1β, IL1RN, and IL10. We used comprehensive sequencing data from the Seattle SNPs database to select tag SNPs that represent all common polymorphisms in the Caucasian population at these loci. Associations with 28 tag SNPs were evaluated in 478 cases and 501 unscreened control individuals, while accounting for population sub-structure using the genomic control method. The samples were also stratified by gender, diagnostic category, and exposure to infectious agents. Significant association was not detected after correcting for multiple comparisons. However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1β - 511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n = 819 cases, 1292 controls; p = 0.0013, OR = 1.24, 95% CI 1.09, 1.41).
KW - Candidate gene
KW - IL-1beta - 511
KW - IL1RA, cytokine
KW - Interleukin
KW - Meta-analysis
KW - Virus
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U2 - 10.1016/j.schres.2006.06.037
DO - 10.1016/j.schres.2006.06.037
M3 - Article
C2 - 16905295
AN - SCOPUS:33750604501
SN - 0920-9964
VL - 88
SP - 235
EP - 244
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -