Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

Jian Wang, Zhuo Lin Liu, Biao Chen

Research output: Contribution to journalArticle

Abstract

The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

Original languageEnglish (US)
Pages (from-to)1757-1759
Number of pages3
JournalNeurology
Volume56
Issue number12
DOIs
StatePublished - Jun 26 2001

ASJC Scopus subject areas

  • Clinical Neurology

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