TY - JOUR
T1 - Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia
AU - Jönsson, Erik G.
AU - Cichon, Sven
AU - Schumacher, Johannes
AU - Jamra, Kami Abou
AU - Schulze, Thomas G.
AU - Deschner, Monica
AU - Forslund, Kaj
AU - Hall, Håkan
AU - Propping, Peter
AU - Czerski, Piotr M.
AU - Dmitrak-Weglarz, Monica
AU - Kapelski, Pawel
AU - Driessen, Martin
AU - Maier, Wolfgang
AU - Hauser, Joanna
AU - Rietschel, Marcella
AU - Nöthen, Markus M.
PY - 2006/1/5
Y1 - 2006/1/5
N2 - A functional promoter polymorphism (-116C/G) of the X-box binding protein 1 gene (XBP1) gene was reported to be associated with schizophrenia in Asian subjects. In a replication attempt, three European case-control samples comprising 2,182 German, Polish, and Swedish subjects, were genotyped for the XBP1 -116C/G polymorphism. Allele and genotype frequencies were compared between schizophrenic patients and control subjects. There were no significant case-control differences in any of the three samples, although in a meta-analysis with previous results comprising 3,612 subjects there was a borderline association between the -116G-containing genotypes and schizophrenia. We conclude that the functional XBP1 gene polymorphism is not of major importance to schizophrenia in the European populations investigated. It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder.
AB - A functional promoter polymorphism (-116C/G) of the X-box binding protein 1 gene (XBP1) gene was reported to be associated with schizophrenia in Asian subjects. In a replication attempt, three European case-control samples comprising 2,182 German, Polish, and Swedish subjects, were genotyped for the XBP1 -116C/G polymorphism. Allele and genotype frequencies were compared between schizophrenic patients and control subjects. There were no significant case-control differences in any of the three samples, although in a meta-analysis with previous results comprising 3,612 subjects there was a borderline association between the -116G-containing genotypes and schizophrenia. We conclude that the functional XBP1 gene polymorphism is not of major importance to schizophrenia in the European populations investigated. It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder.
KW - Bipolar disorder
KW - Case-control association study
KW - Meta-analysis
KW - X-box binding protein 1 gene (XBP1)
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U2 - 10.1002/ajmg.b.30262
DO - 10.1002/ajmg.b.30262
M3 - Article
C2 - 16342282
AN - SCOPUS:30344435574
SN - 1552-4841
VL - 141 B
SP - 71
EP - 75
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 1
ER -