TY - JOUR
T1 - Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
AU - Jamra, Rami Abou
AU - Klein, Katrin
AU - Villela, Angela Wolf
AU - Becker, Tim
AU - Schulze, Thomas G.
AU - Schmael, Christine
AU - Deschner, Monika
AU - Klopp, Norman
AU - Illig, Thomas
AU - Propping, Peter
AU - Cichon, Sven
AU - Rietschel, Marcella
AU - Nöthen, Markus M.
AU - Schumacher, Johannes
PY - 2006/9/5
Y1 - 2006/9/5
N2 - Results from molecular and pharmacological studies point to involvement of the gene coding for the phosphatidylinositol-4-phosphate 5-kinase type II-alpha (PIP5K2A) in the development of schizophrenia and bipolar affective disorder (BPAD). The PIP5K2A gene locus, which is located on chromosomal region 10p12, has been implicated in the development of both disorders by independent linkage and association studies. On a cellular level, PIP5K2A is an enzyme component of the metabolism of inositol phosphate, which has been considered a potential target for the therapeutic action of lithium in BPAD patients. Given that the PIP5K2A gene is a promising candidate for the development of both disorders, we performed an association study between genetic variants at the PIP5K2A locus and 268 patients with schizophrenia, 260 patients with BPAD and 325 ethnically matched healthy controls. We failed to detect association to either disorder using PIP5K2A gene variants through single-marker and haplotype analysis. Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population.
AB - Results from molecular and pharmacological studies point to involvement of the gene coding for the phosphatidylinositol-4-phosphate 5-kinase type II-alpha (PIP5K2A) in the development of schizophrenia and bipolar affective disorder (BPAD). The PIP5K2A gene locus, which is located on chromosomal region 10p12, has been implicated in the development of both disorders by independent linkage and association studies. On a cellular level, PIP5K2A is an enzyme component of the metabolism of inositol phosphate, which has been considered a potential target for the therapeutic action of lithium in BPAD patients. Given that the PIP5K2A gene is a promising candidate for the development of both disorders, we performed an association study between genetic variants at the PIP5K2A locus and 268 patients with schizophrenia, 260 patients with BPAD and 325 ethnically matched healthy controls. We failed to detect association to either disorder using PIP5K2A gene variants through single-marker and haplotype analysis. Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population.
KW - 10p12
KW - Case-control
KW - German
KW - Phosphatidylinositol-4-phosphate 5-kinase type II-alpha
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U2 - 10.1002/ajmg.b.30358
DO - 10.1002/ajmg.b.30358
M3 - Article
C2 - 16823801
AN - SCOPUS:33748933549
SN - 1552-4841
VL - 141
SP - 663
EP - 665
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 6
ER -