Association study between candidate genes on transforming growth factor-β signaling pathway and the risk of non-syndromic cleft lip with or without cleft palate in Chinese populations

Zhu qing Wang, Ping Wang, Yah huei Wu-Chou, Xiao qian Ye, Shang zhi Huang, Bing Shi, Ke Wang, Yuan Yuan, Dong jing Liu, Tao Wu, Hong Wang, Terri H. Beaty

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To explore the association between 10 candidate genes on transforming growth factor-β (TGFB) signaling pathway and non-syndromic cleft lip with or without cleft palate (NSCL/P) among Chinese populations, and to study the gene-environment interaction.

METHODS: A total of 806 Chinese Han NSCL/P trios were ascertained from an international consortium, which conducted a genome-wide association study using a case-parent trio design to investigate the genes affecting risk to NSCL/P. The transmission disequilibrium test (TDT) was used to test for effects of 343 single nucleotide polymorphisms (SNPs) in 10 genes on TGFB signaling pathway including DCN, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, BAMBI, SMAD2, SMAD3 and SMAD4. The conditional regression models were used to test for gene-environment interaction.

RESULTS: For TDT, although 19 SNPs showed nominal significant association with NSCL/P, no significant evidence of association was seen for all SNPs in 806 NSCL/P trios after Bonferroni correction. The interactions between genes and maternal smoking, environmental tobacco smoke, alcohol consumption and multi-vitamin supplementation during pregnancy did not attain statistical significance after correction for multiple comparisons.

CONCLUSION: No evidence for SNP effect of genes on TGFB signaling pathway and significant gene-environment interaction was seen in our data.

Original languageEnglish (US)
Pages (from-to)384-389
Number of pages6
JournalBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Volume47
Issue number3
StatePublished - Jun 18 2015

ASJC Scopus subject areas

  • Medicine(all)

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