TY - JOUR
T1 - Association of white matter microstructural integrity with cognition and dementia
AU - Power, Melinda C.
AU - Su, Dan
AU - Wu, Aozhou
AU - Reid, Robert I.
AU - Jack, Clifford R.
AU - Knopman, David S.
AU - Coresh, Joe
AU - Huang, Juebin
AU - Kantarci, Kejal
AU - Sharrett, Albert Richey
AU - Gottesman, Rebecca G.
AU - Griswold, Mike E.
AU - Mosley, Thomas H.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011–2013 and were followed through 2016–2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.
AB - Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011–2013 and were followed through 2016–2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.
KW - Cognitive decline
KW - Cognitive impairment
KW - DTI
KW - Dementia
KW - MRI
KW - White matter microstructural integrity
UR - http://www.scopus.com/inward/record.url?scp=85072751772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072751772&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2019.08.021
DO - 10.1016/j.neurobiolaging.2019.08.021
M3 - Article
C2 - 31585368
AN - SCOPUS:85072751772
SN - 0197-4580
VL - 83
SP - 63
EP - 72
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -