Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging

Ryan J. Dougherty; Janani Ramachandran; Fangyu Liu; Yang An; Amal A. Wanigatunga; Qu Tian; Murat Bilgel; Eleanor Marie Simonsick; Luigi Ferrucci; Susan M. Resnick; Jennifer A. Schrack

doi:10.1002/dad2.12228

Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging

Ryan J. Dougherty, Janani Ramachandran, Fangyu Liu, Yang An, Amal A. Wanigatunga, Qu Tian, Murat Bilgel, Eleanor Marie Simonsick, Luigi Ferrucci, Susan M. Resnick, Jennifer A. Schrack

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. Methods: One hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and ¹¹C-Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4. Results: Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; P =.011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; P =.321). Discussion: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.

Original language	English (US)
Article number	e12228
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12228
State	Published - 2021

Keywords

apolipoprotein E ε4
biomarkers
motor control
risk factor
walking economy
walking efficiency

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1002/dad2.12228

Cite this

Dougherty, R. J., Ramachandran, J., Liu, F., An, Y., Wanigatunga, A. A., Tian, Q., Bilgel, M., Simonsick, E. M., Ferrucci, L., Resnick, S. M., & Schrack, J. A. (2021). Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article e12228. https://doi.org/10.1002/dad2.12228

Dougherty, RJ, Ramachandran, J, Liu, F, An, Y, Wanigatunga, AA, Tian, Q, Bilgel, M, Simonsick, EM, Ferrucci, L, Resnick, SM & Schrack, JA 2021, 'Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 13, no. 1, e12228. https://doi.org/10.1002/dad2.12228

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title = "Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging",

abstract = "Introduction: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. Methods: One hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and 11C-Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4. Results: Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; P =.011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; P =.321). Discussion: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.",

keywords = "apolipoprotein E ε4, biomarkers, motor control, risk factor, walking economy, walking efficiency",

author = "Dougherty, {Ryan J.} and Janani Ramachandran and Fangyu Liu and Yang An and Wanigatunga, {Amal A.} and Qu Tian and Murat Bilgel and Simonsick, {Eleanor Marie} and Luigi Ferrucci and Resnick, {Susan M.} and Schrack, {Jennifer A.}",

note = "Funding Information: This research was supported by the Intramural Research Program of the National Institute on Aging of the National Institutes of Health and by grant U01AG057545. Data used in the analyses were obtained from the Baltimore Longitudinal Study of Aging, a study performed by the National Institute on Aging Intramural Research Program. Ryan J. Dougherty was supported by an NIA training grant T32AG027668. Funding Information: This research was supported by the Intramural Research Program of the National Institute on Aging of the National Institutes of Health and by grant U01AG057545. Data used in the analyses were obtained from the Baltimore Longitudinal Study of Aging, a study performed by the National Institute on Aging Intramural Research Program. Ryan J. Dougherty was supported by an NIA training grant T32AG027668. Publisher Copyright: {\textcopyright} 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association",

year = "2021",

doi = "10.1002/dad2.12228",

language = "English (US)",

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journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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T1 - Association of walking energetics with amyloid beta status

T2 - Findings from the Baltimore Longitudinal Study of Aging

AU - Dougherty, Ryan J.

AU - Ramachandran, Janani

AU - Liu, Fangyu

AU - An, Yang

AU - Wanigatunga, Amal A.

AU - Tian, Qu

AU - Bilgel, Murat

AU - Simonsick, Eleanor Marie

AU - Ferrucci, Luigi

AU - Resnick, Susan M.

AU - Schrack, Jennifer A.

N1 - Funding Information: This research was supported by the Intramural Research Program of the National Institute on Aging of the National Institutes of Health and by grant U01AG057545. Data used in the analyses were obtained from the Baltimore Longitudinal Study of Aging, a study performed by the National Institute on Aging Intramural Research Program. Ryan J. Dougherty was supported by an NIA training grant T32AG027668. Funding Information: This research was supported by the Intramural Research Program of the National Institute on Aging of the National Institutes of Health and by grant U01AG057545. Data used in the analyses were obtained from the Baltimore Longitudinal Study of Aging, a study performed by the National Institute on Aging Intramural Research Program. Ryan J. Dougherty was supported by an NIA training grant T32AG027668. Publisher Copyright: © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association

PY - 2021

Y1 - 2021

N2 - Introduction: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. Methods: One hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and 11C-Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4. Results: Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; P =.011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; P =.321). Discussion: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.

AB - Introduction: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. Methods: One hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and 11C-Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4. Results: Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; P =.011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; P =.321). Discussion: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.

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KW - motor control

KW - risk factor

KW - walking economy

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Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging

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