Association of visceral adiposity index with new-onset type 2 diabetes and impaired fasting glucose in hypertensive Chinese adults

Chun Zhou, Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Panpan He, Qinqin Li, Di Xie, Min Liang, Guobao Wang, Jing Nie, Chengzhang Liu, Yun Song, Lishun Liu, Binyan Wang, Xiaobin Wang, Xiping Xu, Xianhui Qin

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Visceral adiposity index (VAI) is a reliable indicator for the distribution and function of adipose tissue in the body. The relation of VAI with new-onset type 2 diabetes and new-onset impaired fasting glucose (IFG) remains uncertain. We aimed to investigate the prospective relation of VAI with new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive adults. Methods: A total of 14,838 hypertensive adults free of type 2 diabetes at baseline were included from the China Stroke Primary Prevention Trial. The primary outcome was new-onset type 2 diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose ≥ 7.0 mmol/L at the exit visit. The secondary outcome was new-onset IFG, defined as fasting glucose < 6.1 mmol/L at baseline, while fasting glucose ≥ 6.1 mmol/L and < 7.0 mmol/L at the exit visit. Results: Over a median of 4.5 years’ follow-up, 1612 (10.9%) participants developed type 2 diabetes. When VAI was categorized into quartiles, compared with participants in quartile 1–3 (< 2.80), significantly higher risk of new-onset type 2 diabetes (OR 1.30; 95% CI 1.08–1.56) and new-onset IFG (OR 1.28; 95% CI 1.08–1.52) was found in those in quartile 4 (≥ 2.80). Moreover, the positive associations were consistent in participants with or without single abnormal VAI components, including general obesity, abdominal obesity, elevated triglycerides and low high-density lipoprotein cholesterol (HDL-C) levels; or with different numbers of abnormal VAI components (all P interactions > 0.05). Conclusion: Our study suggested a positive relation of VAI with the risk of new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive patients, independent of its components. Level of evidence: Level III, a well-designed cohort.

Original languageEnglish (US)
Pages (from-to)505-514
Number of pages10
JournalEating and Weight Disorders
Volume27
Issue number2
DOIs
StatePublished - Mar 2022

Keywords

  • Hypertension
  • New-onset impair fasting glucose
  • New-onset type 2 diabetes
  • Visceral adiposity index

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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