Association of urineα1-microglobulin with kidney function decline and mortality in HIV-infected women

Vasantha Jotwani, Rebecca Scherzer, Alison Gump Abraham, Michelle M. Estrella, Michael Bennett, Mardge H. Cohen, Marek Nowicki, Anjali Sharma, Mary Young, Phyllis C. Tien, Joachim H. Ix, Mark J. Sarnak, Chirag Parikh, Michael G. Shlipak

Research output: Contribution to journalArticle

Abstract

Background and objectivesDespite advances in therapy, HIV-infected individuals remain at higher risk for kidney dysfunction than uninfected individuals. It was hypothesized that urine levels ofα1-microglobulin, a biomarker of proximal tubular dysfunction, would predict kidney function decline and mortality risk in HIV-infected and uninfected women. Design, setting, participants, & measurementsIn the Women’s Interagency HIV Study, urineα1-microglobulin and creatinine concentrations were measured in 903 HIV-infected and 287 uninfected women using stored urine from 1999 to 2000, when prevalence of tenofovir use was

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalClinical Journal of the American Society of Nephrology
Volume10
Issue number1
DOIs
StatePublished - 2015
Externally publishedYes

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HIV
Kidney
Tenofovir
Mortality
Urine
Creatinine
Biomarkers
Therapeutics

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Association of urineα1-microglobulin with kidney function decline and mortality in HIV-infected women. / Jotwani, Vasantha; Scherzer, Rebecca; Abraham, Alison Gump; Estrella, Michelle M.; Bennett, Michael; Cohen, Mardge H.; Nowicki, Marek; Sharma, Anjali; Young, Mary; Tien, Phyllis C.; Ix, Joachim H.; Sarnak, Mark J.; Parikh, Chirag; Shlipak, Michael G.

In: Clinical Journal of the American Society of Nephrology, Vol. 10, No. 1, 2015, p. 63-73.

Research output: Contribution to journalArticle

Jotwani, V, Scherzer, R, Abraham, AG, Estrella, MM, Bennett, M, Cohen, MH, Nowicki, M, Sharma, A, Young, M, Tien, PC, Ix, JH, Sarnak, MJ, Parikh, C & Shlipak, MG 2015, 'Association of urineα1-microglobulin with kidney function decline and mortality in HIV-infected women', Clinical Journal of the American Society of Nephrology, vol. 10, no. 1, pp. 63-73. https://doi.org/10.2215/CJN.03220314
Jotwani, Vasantha ; Scherzer, Rebecca ; Abraham, Alison Gump ; Estrella, Michelle M. ; Bennett, Michael ; Cohen, Mardge H. ; Nowicki, Marek ; Sharma, Anjali ; Young, Mary ; Tien, Phyllis C. ; Ix, Joachim H. ; Sarnak, Mark J. ; Parikh, Chirag ; Shlipak, Michael G. / Association of urineα1-microglobulin with kidney function decline and mortality in HIV-infected women. In: Clinical Journal of the American Society of Nephrology. 2015 ; Vol. 10, No. 1. pp. 63-73.
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