Abstract
Some clinical trials have shown that high phytoestrogen intake may decrease serum concentrations of prostate-specific antigen (PSA), and phytoestrogens may also lower prostate cancer risk. It was the aim of this study to examine the relationship between the serum PSA level and urine phytoestrogen concentration in generally healthy U.S. men. Eight hundred twenty-four men, 40+ yr old without prostate cancer, who participated in the 2001-2004 NHANES surveys, were included in the analysis. The association of total PSA, free PSA, and PSA ratio [free PSA/total PSA * 100] with concentrations of isoflavones and lignans (standardized for urinary creatinine concentration) was examined using multivariable-adjusted linear and logistic regression models. The linear regression analyses showed no clear association between creatinine-standardized urinary phytoestrogen concentrations and serum total or free PSA levels or PSA ratio. However, the odds of having a PSA ratio
| Original language | English (US) |
|---|---|
| Pages (from-to) | 813-819 |
| Number of pages | 7 |
| Journal | Nutrition and Cancer |
| Volume | 65 |
| Issue number | 6 |
| DOIs | |
| State | Published - Aug 1 2013 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Oncology
- Cancer Research
Cite this
Association of urinary phytoestrogen concentrations with serum concentrations of prostate-specific antigen in the national health and nutrition examination survey. / Walser-Domjan, Esther; Richard, Aline; Eichholzer, Monika; Platz, Elizabeth A; Linseisen, Jakob; Rohrmann, Sabine.
In: Nutrition and Cancer, Vol. 65, No. 6, 01.08.2013, p. 813-819.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of urinary phytoestrogen concentrations with serum concentrations of prostate-specific antigen in the national health and nutrition examination survey
AU - Walser-Domjan, Esther
AU - Richard, Aline
AU - Eichholzer, Monika
AU - Platz, Elizabeth A
AU - Linseisen, Jakob
AU - Rohrmann, Sabine
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Some clinical trials have shown that high phytoestrogen intake may decrease serum concentrations of prostate-specific antigen (PSA), and phytoestrogens may also lower prostate cancer risk. It was the aim of this study to examine the relationship between the serum PSA level and urine phytoestrogen concentration in generally healthy U.S. men. Eight hundred twenty-four men, 40+ yr old without prostate cancer, who participated in the 2001-2004 NHANES surveys, were included in the analysis. The association of total PSA, free PSA, and PSA ratio [free PSA/total PSA * 100] with concentrations of isoflavones and lignans (standardized for urinary creatinine concentration) was examined using multivariable-adjusted linear and logistic regression models. The linear regression analyses showed no clear association between creatinine-standardized urinary phytoestrogen concentrations and serum total or free PSA levels or PSA ratio. However, the odds of having a PSA ratio
AB - Some clinical trials have shown that high phytoestrogen intake may decrease serum concentrations of prostate-specific antigen (PSA), and phytoestrogens may also lower prostate cancer risk. It was the aim of this study to examine the relationship between the serum PSA level and urine phytoestrogen concentration in generally healthy U.S. men. Eight hundred twenty-four men, 40+ yr old without prostate cancer, who participated in the 2001-2004 NHANES surveys, were included in the analysis. The association of total PSA, free PSA, and PSA ratio [free PSA/total PSA * 100] with concentrations of isoflavones and lignans (standardized for urinary creatinine concentration) was examined using multivariable-adjusted linear and logistic regression models. The linear regression analyses showed no clear association between creatinine-standardized urinary phytoestrogen concentrations and serum total or free PSA levels or PSA ratio. However, the odds of having a PSA ratio
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UR - http://www.scopus.com/inward/citedby.url?scp=84882334408&partnerID=8YFLogxK
U2 - 10.1080/01635581.2013.801999
DO - 10.1080/01635581.2013.801999
M3 - Article
C2 - 23909724
AN - SCOPUS:84882334408
VL - 65
SP - 813
EP - 819
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 6
ER -