TY - JOUR
T1 - Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia
AU - Schwab, Sibylle G.
AU - Mondabon, Stephanie
AU - Knapp, Michael
AU - Albus, Margot
AU - Hallmayer, Joachim
AU - Borrmann-Hassenbach, Margitta
AU - Trixler, Matyas
AU - Groß, Magdalena
AU - Schulze, Thomas G.
AU - Rietschel, Marcella
AU - Lerer, Bernard
AU - Maier, Wolfgang
AU - Wildenauer, Dieter B.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Background: Tumor necrosis factor alpha (TNFα), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFα gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]. Methods: Association of the -G308A TNFα gene and the lymphotoxin alpha (LTα)+A252G gene polymorphisms with schizophrenia was studied in 79 sib pair families with linkage in the MHC region and in 128 trio families using the transmission disequilibrium test (TDT). Results: Weak association of the common G allele was detected for TNFα -G308A in both samples independently with borderline significance in the sib pair families (0.064) and with a nominally significant value of P=0.022 in the trio families. Combining both samples produced P=0.003, while LTα+A252G, located approximately 2-3 kb distally, revealed P=0.03 and the two locus haplotype yielded a P value of 0.001. Conclusion: Our data suggests association of the common G allele of the -G308A TNFα gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFα gene or another gene in the MHC region cannot be excluded.
AB - Background: Tumor necrosis factor alpha (TNFα), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFα gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]. Methods: Association of the -G308A TNFα gene and the lymphotoxin alpha (LTα)+A252G gene polymorphisms with schizophrenia was studied in 79 sib pair families with linkage in the MHC region and in 128 trio families using the transmission disequilibrium test (TDT). Results: Weak association of the common G allele was detected for TNFα -G308A in both samples independently with borderline significance in the sib pair families (0.064) and with a nominally significant value of P=0.022 in the trio families. Combining both samples produced P=0.003, while LTα+A252G, located approximately 2-3 kb distally, revealed P=0.03 and the two locus haplotype yielded a P value of 0.001. Conclusion: Our data suggests association of the common G allele of the -G308A TNFα gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFα gene or another gene in the MHC region cannot be excluded.
KW - Association
KW - Cytokines
KW - Linkage disequilibrium
KW - LTα
KW - Schizophrenia
KW - TNFα
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U2 - 10.1016/S0920-9964(02)00534-0
DO - 10.1016/S0920-9964(02)00534-0
M3 - Article
C2 - 14623370
AN - SCOPUS:10744219906
SN - 0920-9964
VL - 65
SP - 19
EP - 25
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -