Association of total cholesterol/high-density lipoprotein cholesterol ratio with proximal coronary atherosclerosis detected by multislice computed tomography

Deepu Nair, Thomas P. Carrigan, Ronan J. Curtin, Zoran B. Popovic, Stacie Kuzmiak, Paul Schoenhagen, Scott D. Flamm, Milind Y. Desai

Research output: Contribution to journalArticlepeer-review

Abstract

The authors assessed the association between an elevated total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio (≥4) and proximal coronary artery disease (CAD), as observed on multislice computed tomography. Coronary multislice computed tomographic angiography (96% on 40- or 64-slice) was performed in 295 individuals (39% women; mean age, 54±13 years) without documented CAD who were referred for coronary evaluation. Significant CAD was defined as ≥50% stenosis in the left main, proximal left anterior descending, or ≥2 epicardial vessels. Proximal plaque was defined as presence of any plaque in left main or proximal left anterior descending vessels. Individuals with an elevated TC/HDL-C ratio vs those without had a higher prevalence of proximal plaque (62% vs 48%, P=.04) and significant CAD (19% vs 9%, P=.009). On multivariate logistic regression analysis, only age, sex, and TC/HDL-C ratio ≥4 were associated with significant CAD and proximal plaque.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalPreventive Cardiology
Volume12
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Public Health, Environmental and Occupational Health

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