Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder

D. Bengel, B. D. Greenberg, G. Corá-Locatelli, M. Altemus, A. Heils, Q. Li, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

Abstract

Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved in its etiology. The serotonin (5-HT) transporter (5-HTT), which is the key modulator of serotonergic neurotransmission, is the target for serotonin reuptake inhibiting drugs (SRIs) that are uniquely effective in the treatment of OCD. In this preliminary study we report an association of a functional polymorphism in the 5-HTT 5' regulatory-region and OCD. Seventy-five OCD Caucasian patients and 397 ethnically-matched individuals from a non-patient control group were genotyped for the 5-HTTLPR. Population-based association analysis revealed that patients with OCD were more likely to carry two copies of the long allele (l) as compared to controls (46.7% vs 32.3%: χ2 = 5.19, P = 0.023). This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD.

Original languageEnglish (US)
Pages (from-to)463-466
Number of pages4
JournalMolecular psychiatry
Volume4
Issue number5
DOIs
StatePublished - 1999

Keywords

  • Association study
  • Genetics
  • Obsessive-compulsive disorder
  • Serotonin transporter

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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