Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function

The CARDIA study

Jared P. Reis, Norrina Allen, Bethany B. Gibbs, Samuel S. Gidding, Joyce M. Lee, Cora E. Lewis, Joao Lima, Donald Lloyd-Jones, Catherine M. Loria, Tiffany M. Powell-Wiley, Shishir Sharma, Gina Wei, Kiang Liu

Research output: Contribution to journalArticle

Abstract

Objective: Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function. Methods: Participants of CARDIA were 18-30 years when they underwent a baseline examination in 1985-86. Seven follow-up examinations were conducted every 2-5 years. Results: Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m-2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P <0.001), LV volume (P <0.001), LV mass-to-volume ratio (P <0.001), left atrial dimension (P <0.001), and ejection fraction (P <0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (P = 0.003) and a trend for a lower ejection fraction (P = 0.07). Conclusions: A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.

Original languageEnglish (US)
Pages (from-to)2434-2440
Number of pages7
JournalObesity
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2014

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Adiposity
Obesity
Ventricular Remodeling
Waist Circumference

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Reis, J. P., Allen, N., Gibbs, B. B., Gidding, S. S., Lee, J. M., Lewis, C. E., ... Liu, K. (2014). Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study. Obesity, 22(11), 2434-2440. https://doi.org/10.1002/oby.20865

Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function : The CARDIA study. / Reis, Jared P.; Allen, Norrina; Gibbs, Bethany B.; Gidding, Samuel S.; Lee, Joyce M.; Lewis, Cora E.; Lima, Joao; Lloyd-Jones, Donald; Loria, Catherine M.; Powell-Wiley, Tiffany M.; Sharma, Shishir; Wei, Gina; Liu, Kiang.

In: Obesity, Vol. 22, No. 11, 01.11.2014, p. 2434-2440.

Research output: Contribution to journalArticle

Reis, JP, Allen, N, Gibbs, BB, Gidding, SS, Lee, JM, Lewis, CE, Lima, J, Lloyd-Jones, D, Loria, CM, Powell-Wiley, TM, Sharma, S, Wei, G & Liu, K 2014, 'Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study', Obesity, vol. 22, no. 11, pp. 2434-2440. https://doi.org/10.1002/oby.20865
Reis, Jared P. ; Allen, Norrina ; Gibbs, Bethany B. ; Gidding, Samuel S. ; Lee, Joyce M. ; Lewis, Cora E. ; Lima, Joao ; Lloyd-Jones, Donald ; Loria, Catherine M. ; Powell-Wiley, Tiffany M. ; Sharma, Shishir ; Wei, Gina ; Liu, Kiang. / Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function : The CARDIA study. In: Obesity. 2014 ; Vol. 22, No. 11. pp. 2434-2440.
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