Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study

Jared P. Reis, Norrina Allen, Bethany B. Gibbs, Samuel S. Gidding, Joyce M. Lee, Cora E. Lewis, Joao Lima, Donald Lloyd-Jones, Catherine M. Loria, Tiffany M. Powell-Wiley, Shishir Sharma, Gina Wei, Kiang Liu

Research output: Contribution to journalArticle

Abstract

Objective: Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function. Methods: Participants of CARDIA were 18-30 years when they underwent a baseline examination in 1985-86. Seven follow-up examinations were conducted every 2-5 years. Results: Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m-2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P < 0.001), LV volume (P < 0.001), LV mass-to-volume ratio (P < 0.001), left atrial dimension (P < 0.001), and ejection fraction (P < 0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (P = 0.003) and a trend for a lower ejection fraction (P = 0.07). Conclusions: A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.

Original languageEnglish (US)
Pages (from-to)2434-2440
Number of pages7
JournalObesity
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2014

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Reis, J. P., Allen, N., Gibbs, B. B., Gidding, S. S., Lee, J. M., Lewis, C. E., Lima, J., Lloyd-Jones, D., Loria, C. M., Powell-Wiley, T. M., Sharma, S., Wei, G., & Liu, K. (2014). Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study. Obesity, 22(11), 2434-2440. https://doi.org/10.1002/oby.20865