Association of the autoimmune disease scleroderma with an immunologic response to cancer

Christine Joseph, Erika Darrah, Ami A. Shah, Andrew D. Skora, Livia A. Casciola-Rosen, Fredrick M. Wigley, Francesco Boin, Andrea Fava, Chris Thoburn, Isaac Kinde, Yuchen Jiao, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Antony Rosen

Research output: Contribution to journalArticlepeer-review

232 Scopus citations


Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Scleroderma is an autoimmune connective tissue disease in which patients make antibodies to a limited group of autoantigens, including RPC1, encoded by the POLR3A gene. As patients with scleroderma and antibodies against RPC1 are at increased risk for cancer, we hypothesized that the "foreign" antigens in this autoimmune disease are encoded by somatically mutated genes in the patients' incipient cancers. Studying cancers from scleroderma patients, we found genetic alterations of the POLR3A locus in six of eight patients with antibodies to RPC1 but not in eight patients without antibodies to RPC1. Analyses of peripheral blood lymphocytes and serum suggested that POLR3A mutations triggered cellular immunity and cross-reactive humoral immune responses. These results offer insight into the pathogenesis of scleroderma and provide support for the idea that acquired immunity helps to control naturally occurring cancers.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
Issue number6167
StatePublished - 2014

ASJC Scopus subject areas

  • General


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