Association of the APC tumor suppressor protein with catenins

Research output: Contribution to journalArticle

Abstract

Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product. Two cellular proteins that associate with APC were identified by nucleotide sequence analysis and peptide mapping as the E-cadherin-associated proteins α- and β-catenin. A27-residue fragment ofAPC containing a 1 5-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion.

Original languageEnglish (US)
Pages (from-to)1734-1737
Number of pages4
JournalScience
Volume262
Issue number5140
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

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