Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study

Christina M. Parrinello, Alan L. Landay, Howard N. Hodis, Stephen J Gange, Philip J. Norris, Mary Young, Kathryn Anastos, Phyllis C. Tien, Xiaonan Xue, Jason Lazar, Lorie Benning, Russell P. Tracy, Robert C. Kaplan

Research output: Contribution to journalArticle

Abstract

Objective: We examined serum lipids in association with carotid artery intima-media thickness (CIMT) in HIV-infected and HIV-uninfected women. Methods: In 2003-4, among 1827 Women's Interagency HIV Study participants, we measured CIMT and lipids (high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), non-HDL-c). A subset of 520 treated HIV-infected women had pre-1997 lipid measures. We used multivariable linear regression to examine associations between lipids and CIMT. Results: In HIV-uninfected women, higher TC, LDL-c and non-HDL-c were associated with increased CIMT. Among HIV-infected women, associations of lipids with CIMT were observed in treated but not untreated women. Among the HIV-infected women treated in 2003-4, CIMT was associated both with lipids measured a decade earlier in infection, and with late lipid measurements. Conclusion: Among HIV-infected women, hyperlipidemia is most strongly associated with subclinical atherosclerosis in treated women. Among treated women, the association appeared strongest early in the disease course.

Original languageEnglish (US)
Pages (from-to)408-411
Number of pages4
JournalAtherosclerosis
Volume225
Issue number2
DOIs
StatePublished - Dec 2012

Fingerprint

Atherosclerosis
Carotid Intima-Media Thickness
HIV
Lipids
Carotid Arteries
LDL Cholesterol
Cholesterol
Hyperlipidemias
HDL Cholesterol
Linear Models
Infection
Serum

Keywords

  • Cardiovascular diseases
  • Carotid arteries
  • HAART
  • HIV
  • Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study. / Parrinello, Christina M.; Landay, Alan L.; Hodis, Howard N.; Gange, Stephen J; Norris, Philip J.; Young, Mary; Anastos, Kathryn; Tien, Phyllis C.; Xue, Xiaonan; Lazar, Jason; Benning, Lorie; Tracy, Russell P.; Kaplan, Robert C.

In: Atherosclerosis, Vol. 225, No. 2, 12.2012, p. 408-411.

Research output: Contribution to journalArticle

Parrinello, CM, Landay, AL, Hodis, HN, Gange, SJ, Norris, PJ, Young, M, Anastos, K, Tien, PC, Xue, X, Lazar, J, Benning, L, Tracy, RP & Kaplan, RC 2012, 'Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study', Atherosclerosis, vol. 225, no. 2, pp. 408-411. https://doi.org/10.1016/j.atherosclerosis.2012.09.035
Parrinello, Christina M. ; Landay, Alan L. ; Hodis, Howard N. ; Gange, Stephen J ; Norris, Philip J. ; Young, Mary ; Anastos, Kathryn ; Tien, Phyllis C. ; Xue, Xiaonan ; Lazar, Jason ; Benning, Lorie ; Tracy, Russell P. ; Kaplan, Robert C. / Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study. In: Atherosclerosis. 2012 ; Vol. 225, No. 2. pp. 408-411.
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