Association of subclinical atherosclerosis using carotid intima-media thickness, carotid plaque, and coronary calcium score with left ventricular dyssynchrony

The multi-ethnic Study of Atherosclerosis

Ravi K. Sharma, Sirisha Donekal, Boaz D. Rosen, Matthew C. Tattersall, Gustavo J. Volpe, Bharath Ambale Venkatesh, Khurram Nasir, Colin O. Wu, Joseph F. Polak, Claudia E. Korcarz, James H. Stein, James Carr, Karol E. Watson, David A. Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

Background: The role of atherosclerosis in the progression of global left ventricular dysfunction and cardiovascular events has been well recognized. Left ventricular (LV) dyssynchrony is a measure of regional myocardial dysfunction. Our objective was to investigate the relationship of subclinical atherosclerosis with mechanical LV dyssynchrony in a population-based asymptomatic multi-ethnic cohort. Methods and Results: Participants of the Multi-Ethnic Study of Atherosclerosis (MESA) at exam 5 were evaluated using 1.5T cardiac magnetic resonance (CMR) imaging, carotid ultrasound (n=2062) for common carotid artery (CCA) and internal carotid artery (ICA) intima-media thickness (IMT), and cardiac computed tomography (n=2039) for coronary artery calcium (CAC) assessment (Agatston method). Dyssynchrony indices were defined as the standard deviation of time to peak systolic circumferential strain (SD-TPS) and the difference between maximum and minimum (max-min) time to peak strain using harmonic phase imaging in 12 segments (3-slices×4 segments). Multivariable regression analyses were performed to assess associations after adjusting for participant demographics, cardiovascular risk factors, LV mass, and ejection fraction. In multivariable analyses, SD-TPS was significantly related to measures of atherosclerosis, including CCA-IMT (8.7ms/mm change in IMT, p=0.020), ICA-IMT (19.2ms/mm change in IMT, p

Original languageEnglish (US)
Pages (from-to)412-418
Number of pages7
JournalAtherosclerosis
Volume239
Issue number2
DOIs
StatePublished - Apr 1 2015

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Carotid Intima-Media Thickness
Atherosclerosis
Calcium
Common Carotid Artery
Internal Carotid Artery
Left Ventricular Dysfunction
Stroke Volume
Coronary Vessels
Tomography
Regression Analysis
Magnetic Resonance Imaging
Demography
Population

Keywords

  • Atherosclerosis
  • CAC
  • Carotid IMT
  • CCA
  • CMR
  • Coronary calcium score
  • CT
  • EGFR
  • HDL
  • HF
  • ICA
  • IMT
  • LBBB
  • Left ventricular dyssynchrony
  • LV
  • Max-min
  • SD
  • SD-TPS

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of subclinical atherosclerosis using carotid intima-media thickness, carotid plaque, and coronary calcium score with left ventricular dyssynchrony : The multi-ethnic Study of Atherosclerosis. / Sharma, Ravi K.; Donekal, Sirisha; Rosen, Boaz D.; Tattersall, Matthew C.; Volpe, Gustavo J.; Ambale Venkatesh, Bharath; Nasir, Khurram; Wu, Colin O.; Polak, Joseph F.; Korcarz, Claudia E.; Stein, James H.; Carr, James; Watson, Karol E.; Bluemke, David A.; Lima, Joao.

In: Atherosclerosis, Vol. 239, No. 2, 01.04.2015, p. 412-418.

Research output: Contribution to journalArticle

Sharma, Ravi K. ; Donekal, Sirisha ; Rosen, Boaz D. ; Tattersall, Matthew C. ; Volpe, Gustavo J. ; Ambale Venkatesh, Bharath ; Nasir, Khurram ; Wu, Colin O. ; Polak, Joseph F. ; Korcarz, Claudia E. ; Stein, James H. ; Carr, James ; Watson, Karol E. ; Bluemke, David A. ; Lima, Joao. / Association of subclinical atherosclerosis using carotid intima-media thickness, carotid plaque, and coronary calcium score with left ventricular dyssynchrony : The multi-ethnic Study of Atherosclerosis. In: Atherosclerosis. 2015 ; Vol. 239, No. 2. pp. 412-418.
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abstract = "Background: The role of atherosclerosis in the progression of global left ventricular dysfunction and cardiovascular events has been well recognized. Left ventricular (LV) dyssynchrony is a measure of regional myocardial dysfunction. Our objective was to investigate the relationship of subclinical atherosclerosis with mechanical LV dyssynchrony in a population-based asymptomatic multi-ethnic cohort. Methods and Results: Participants of the Multi-Ethnic Study of Atherosclerosis (MESA) at exam 5 were evaluated using 1.5T cardiac magnetic resonance (CMR) imaging, carotid ultrasound (n=2062) for common carotid artery (CCA) and internal carotid artery (ICA) intima-media thickness (IMT), and cardiac computed tomography (n=2039) for coronary artery calcium (CAC) assessment (Agatston method). Dyssynchrony indices were defined as the standard deviation of time to peak systolic circumferential strain (SD-TPS) and the difference between maximum and minimum (max-min) time to peak strain using harmonic phase imaging in 12 segments (3-slices×4 segments). Multivariable regression analyses were performed to assess associations after adjusting for participant demographics, cardiovascular risk factors, LV mass, and ejection fraction. In multivariable analyses, SD-TPS was significantly related to measures of atherosclerosis, including CCA-IMT (8.7ms/mm change in IMT, p=0.020), ICA-IMT (19.2ms/mm change in IMT, p",
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T1 - Association of subclinical atherosclerosis using carotid intima-media thickness, carotid plaque, and coronary calcium score with left ventricular dyssynchrony

T2 - The multi-ethnic Study of Atherosclerosis

AU - Sharma, Ravi K.

AU - Donekal, Sirisha

AU - Rosen, Boaz D.

AU - Tattersall, Matthew C.

AU - Volpe, Gustavo J.

AU - Ambale Venkatesh, Bharath

AU - Nasir, Khurram

AU - Wu, Colin O.

AU - Polak, Joseph F.

AU - Korcarz, Claudia E.

AU - Stein, James H.

AU - Carr, James

AU - Watson, Karol E.

AU - Bluemke, David A.

AU - Lima, Joao

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: The role of atherosclerosis in the progression of global left ventricular dysfunction and cardiovascular events has been well recognized. Left ventricular (LV) dyssynchrony is a measure of regional myocardial dysfunction. Our objective was to investigate the relationship of subclinical atherosclerosis with mechanical LV dyssynchrony in a population-based asymptomatic multi-ethnic cohort. Methods and Results: Participants of the Multi-Ethnic Study of Atherosclerosis (MESA) at exam 5 were evaluated using 1.5T cardiac magnetic resonance (CMR) imaging, carotid ultrasound (n=2062) for common carotid artery (CCA) and internal carotid artery (ICA) intima-media thickness (IMT), and cardiac computed tomography (n=2039) for coronary artery calcium (CAC) assessment (Agatston method). Dyssynchrony indices were defined as the standard deviation of time to peak systolic circumferential strain (SD-TPS) and the difference between maximum and minimum (max-min) time to peak strain using harmonic phase imaging in 12 segments (3-slices×4 segments). Multivariable regression analyses were performed to assess associations after adjusting for participant demographics, cardiovascular risk factors, LV mass, and ejection fraction. In multivariable analyses, SD-TPS was significantly related to measures of atherosclerosis, including CCA-IMT (8.7ms/mm change in IMT, p=0.020), ICA-IMT (19.2ms/mm change in IMT, p

AB - Background: The role of atherosclerosis in the progression of global left ventricular dysfunction and cardiovascular events has been well recognized. Left ventricular (LV) dyssynchrony is a measure of regional myocardial dysfunction. Our objective was to investigate the relationship of subclinical atherosclerosis with mechanical LV dyssynchrony in a population-based asymptomatic multi-ethnic cohort. Methods and Results: Participants of the Multi-Ethnic Study of Atherosclerosis (MESA) at exam 5 were evaluated using 1.5T cardiac magnetic resonance (CMR) imaging, carotid ultrasound (n=2062) for common carotid artery (CCA) and internal carotid artery (ICA) intima-media thickness (IMT), and cardiac computed tomography (n=2039) for coronary artery calcium (CAC) assessment (Agatston method). Dyssynchrony indices were defined as the standard deviation of time to peak systolic circumferential strain (SD-TPS) and the difference between maximum and minimum (max-min) time to peak strain using harmonic phase imaging in 12 segments (3-slices×4 segments). Multivariable regression analyses were performed to assess associations after adjusting for participant demographics, cardiovascular risk factors, LV mass, and ejection fraction. In multivariable analyses, SD-TPS was significantly related to measures of atherosclerosis, including CCA-IMT (8.7ms/mm change in IMT, p=0.020), ICA-IMT (19.2ms/mm change in IMT, p

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