Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity

A potential mechanism for increased vascular disease

Kiran Musunuru, Wendy S Post, William Raymond Herzog, Haiqing Shen, Jeffrey R. O'Connell, Patrick F. McArdle, Kathleen A. Ryan, Quince Gibson, Yu Ching Cheng, Elizabeth Clearfield, Andrew D. Johnson, Geoffrey Tofler, Qiong Yang, Christopher J. O'Donnell, Diane M Becker, Lisa Yanek, Lewis Becker, Nauder Faraday, Lawrence F. Bielak, Patricia A. Peyser & 2 others Alan R. Shuldiner, Braxton D. Mitchell

Research output: Contribution to journalArticle

Abstract

Background-Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations. Methods and Results-Subjects in the initial population included 1402 asymptomatic Amish adults in whom we measured platelet reactivity (n=788) and coronary artery calcification (CAC) (n=939). Platelet reactivity on agonist stimulation was measured by impedance aggregometry, and CAC was measured by electron beam CT. Twenty-nine SNPs at the 9p21.3 locus were genotyped using the Affymetrix 500K array. Twelve correlated SNPs in the locus were significantly associated with platelet reactivity (all P

Original languageEnglish (US)
Pages (from-to)445-453
Number of pages9
JournalCirculation: Cardiovascular Genetics
Volume3
Issue number5
DOIs
StatePublished - Oct 2010

Fingerprint

Vascular Diseases
Single Nucleotide Polymorphism
Blood Platelets
Chromosomes
Coronary Vessels
Amish
Genome-Wide Association Study
Electric Impedance
Population
Stroke
Electrons

Keywords

  • Blood platelets
  • Cardiovascular diseases
  • Coronary disease
  • Genetics
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)
  • Genetics

Cite this

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity : A potential mechanism for increased vascular disease. / Musunuru, Kiran; Post, Wendy S; Herzog, William Raymond; Shen, Haiqing; O'Connell, Jeffrey R.; McArdle, Patrick F.; Ryan, Kathleen A.; Gibson, Quince; Cheng, Yu Ching; Clearfield, Elizabeth; Johnson, Andrew D.; Tofler, Geoffrey; Yang, Qiong; O'Donnell, Christopher J.; Becker, Diane M; Yanek, Lisa; Becker, Lewis; Faraday, Nauder; Bielak, Lawrence F.; Peyser, Patricia A.; Shuldiner, Alan R.; Mitchell, Braxton D.

In: Circulation: Cardiovascular Genetics, Vol. 3, No. 5, 10.2010, p. 445-453.

Research output: Contribution to journalArticle

Musunuru, K, Post, WS, Herzog, WR, Shen, H, O'Connell, JR, McArdle, PF, Ryan, KA, Gibson, Q, Cheng, YC, Clearfield, E, Johnson, AD, Tofler, G, Yang, Q, O'Donnell, CJ, Becker, DM, Yanek, L, Becker, L, Faraday, N, Bielak, LF, Peyser, PA, Shuldiner, AR & Mitchell, BD 2010, 'Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: A potential mechanism for increased vascular disease', Circulation: Cardiovascular Genetics, vol. 3, no. 5, pp. 445-453. https://doi.org/10.1161/CIRCGENETICS.109.923508
Musunuru, Kiran ; Post, Wendy S ; Herzog, William Raymond ; Shen, Haiqing ; O'Connell, Jeffrey R. ; McArdle, Patrick F. ; Ryan, Kathleen A. ; Gibson, Quince ; Cheng, Yu Ching ; Clearfield, Elizabeth ; Johnson, Andrew D. ; Tofler, Geoffrey ; Yang, Qiong ; O'Donnell, Christopher J. ; Becker, Diane M ; Yanek, Lisa ; Becker, Lewis ; Faraday, Nauder ; Bielak, Lawrence F. ; Peyser, Patricia A. ; Shuldiner, Alan R. ; Mitchell, Braxton D. / Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity : A potential mechanism for increased vascular disease. In: Circulation: Cardiovascular Genetics. 2010 ; Vol. 3, No. 5. pp. 445-453.
@article{9745a006a4a34a199b0d4718adf224dc,
title = "Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: A potential mechanism for increased vascular disease",
abstract = "Background-Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations. Methods and Results-Subjects in the initial population included 1402 asymptomatic Amish adults in whom we measured platelet reactivity (n=788) and coronary artery calcification (CAC) (n=939). Platelet reactivity on agonist stimulation was measured by impedance aggregometry, and CAC was measured by electron beam CT. Twenty-nine SNPs at the 9p21.3 locus were genotyped using the Affymetrix 500K array. Twelve correlated SNPs in the locus were significantly associated with platelet reactivity (all P",
keywords = "Blood platelets, Cardiovascular diseases, Coronary disease, Genetics, Stroke",
author = "Kiran Musunuru and Post, {Wendy S} and Herzog, {William Raymond} and Haiqing Shen and O'Connell, {Jeffrey R.} and McArdle, {Patrick F.} and Ryan, {Kathleen A.} and Quince Gibson and Cheng, {Yu Ching} and Elizabeth Clearfield and Johnson, {Andrew D.} and Geoffrey Tofler and Qiong Yang and O'Donnell, {Christopher J.} and Becker, {Diane M} and Lisa Yanek and Lewis Becker and Nauder Faraday and Bielak, {Lawrence F.} and Peyser, {Patricia A.} and Shuldiner, {Alan R.} and Mitchell, {Braxton D.}",
year = "2010",
month = "10",
doi = "10.1161/CIRCGENETICS.109.923508",
language = "English (US)",
volume = "3",
pages = "445--453",
journal = "Circulation. Genomic and precision medicine",
issn = "1942-325X",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "5",

}

TY - JOUR

T1 - Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity

T2 - A potential mechanism for increased vascular disease

AU - Musunuru, Kiran

AU - Post, Wendy S

AU - Herzog, William Raymond

AU - Shen, Haiqing

AU - O'Connell, Jeffrey R.

AU - McArdle, Patrick F.

AU - Ryan, Kathleen A.

AU - Gibson, Quince

AU - Cheng, Yu Ching

AU - Clearfield, Elizabeth

AU - Johnson, Andrew D.

AU - Tofler, Geoffrey

AU - Yang, Qiong

AU - O'Donnell, Christopher J.

AU - Becker, Diane M

AU - Yanek, Lisa

AU - Becker, Lewis

AU - Faraday, Nauder

AU - Bielak, Lawrence F.

AU - Peyser, Patricia A.

AU - Shuldiner, Alan R.

AU - Mitchell, Braxton D.

PY - 2010/10

Y1 - 2010/10

N2 - Background-Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations. Methods and Results-Subjects in the initial population included 1402 asymptomatic Amish adults in whom we measured platelet reactivity (n=788) and coronary artery calcification (CAC) (n=939). Platelet reactivity on agonist stimulation was measured by impedance aggregometry, and CAC was measured by electron beam CT. Twenty-nine SNPs at the 9p21.3 locus were genotyped using the Affymetrix 500K array. Twelve correlated SNPs in the locus were significantly associated with platelet reactivity (all P

AB - Background-Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations. Methods and Results-Subjects in the initial population included 1402 asymptomatic Amish adults in whom we measured platelet reactivity (n=788) and coronary artery calcification (CAC) (n=939). Platelet reactivity on agonist stimulation was measured by impedance aggregometry, and CAC was measured by electron beam CT. Twenty-nine SNPs at the 9p21.3 locus were genotyped using the Affymetrix 500K array. Twelve correlated SNPs in the locus were significantly associated with platelet reactivity (all P

KW - Blood platelets

KW - Cardiovascular diseases

KW - Coronary disease

KW - Genetics

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=78649354925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649354925&partnerID=8YFLogxK

U2 - 10.1161/CIRCGENETICS.109.923508

DO - 10.1161/CIRCGENETICS.109.923508

M3 - Article

VL - 3

SP - 445

EP - 453

JO - Circulation. Genomic and precision medicine

JF - Circulation. Genomic and precision medicine

SN - 1942-325X

IS - 5

ER -