Association of serum uric acid with increased risk of cancer among hypertensive Chinese

Juan Yang, Yupeng Wang, Qianqian Zhao, Xianglin Zhang, Xiaobin Wang, Xianhui Qin, Rong Zhang, Lin Shen, Xiaodong Jiang, Hua Jiang, Yu Lei, Binyan Wang, Jin Gu, Fan Fan Hou, Yong Huo, Wei Gao, Xiping Xu

Research output: Contribution to journalArticle

Abstract

Several large prospective studies show an association between serum uric acid (SUA) and cancer, however there is a lack of evidence in China. We aimed to investigate the effects of SUA levels on cancer incidence and mortality in China. This study included 20,577 adult hypertensive patients with valid SUA measurements who participated in the China Stroke Primary Prevention Trial where subjects were randomly assigned to receive a double-blind treatment of either 10 mg enalapril (n = 10,286) or 10.8 mg enalapril-folic acid (n = 10,291). Subjects were prospectively followed for a median of 4.5 years. Cox proportional hazards models were used to calculate hazards ratios (HR) of cancer risk associated with SUA. A total of 232 participants developed cancer. SUA was independently associated with increased cancer risk in the enalapril group [HR: 1.12, (95% CI: 1.03–1.22)]. Compared to the lowest tertile, combined subjects with SUA levels from the upper two tertiles had a higher risk of cancer in the enalapril group [T2 + T3: HR: 1.58, (95% CI: 1.02–2.47)]. In cancer site-specific analyses, a positive association of SUA levels with digestive cancer and all fatal cancer was also observed [HR: 1.18, (95% CI: 1.09–1.27); HR: 1.15, (95% CI: 1.03–1.28), respectively] in the enalapril group. Interestingly, SUA levels were not associated with the risk of cancer or related mortality in the enalapril folic acid group. Our results suggest that elevated SUA is independently and positively associated with the risk of total cancer incidence, digestive cancer incidence and cancer mortality among hypertensive Chinese.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalInternational Journal of Cancer
Volume141
Issue number1
DOIs
StatePublished - Jul 1 2017

Keywords

  • Chinese
  • cancer incidence
  • cancer mortality
  • hypertension
  • serum uric acid

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Yang, J., Wang, Y., Zhao, Q., Zhang, X., Wang, X., Qin, X., Zhang, R., Shen, L., Jiang, X., Jiang, H., Lei, Y., Wang, B., Gu, J., Hou, F. F., Huo, Y., Gao, W., & Xu, X. (2017). Association of serum uric acid with increased risk of cancer among hypertensive Chinese. International Journal of Cancer, 141(1), 112-120. https://doi.org/10.1002/ijc.30731