Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: Clinical significance determined in a follow-up study

Qingzhong Xiao, Kaushik Mandal, Georg Schett, Manuel Mayr, Georg Wick, Friedrich Oberhollenzer, Johann Willeit, Stefan Kiechl, Qingbo Xu

Research output: Contribution to journalArticle

Abstract

Background and Purpose - Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis. In the current evaluation, we tested the hypothesis that sHSP60 levels are associated with the progression of carotid arteriosclerosis, prospectively. Methods - The association of sHSP60 with early atherogenesis (5-year development and progression of nonstenotic carotid plaques) was investigated as part of the population-based prospective Bruneck Study. The current study focused on the follow-up period between 1995 and 2000 and, thus, included 684 subjects. Results - sHSP60 levels measured in 1995 and 2000 were highly correlated (r=0.40; P

Original languageEnglish (US)
Pages (from-to)2571-2576
Number of pages6
JournalStroke
Volume36
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Chaperonin 60
Carotid Artery Diseases
Arteriosclerosis
Atherosclerosis
Prospective Studies
Serum
Population

Keywords

  • Atherosclerosis
  • Follow-up
  • Heat shock protein
  • Progression

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Association of serum-soluble heat shock protein 60 with carotid atherosclerosis : Clinical significance determined in a follow-up study. / Xiao, Qingzhong; Mandal, Kaushik; Schett, Georg; Mayr, Manuel; Wick, Georg; Oberhollenzer, Friedrich; Willeit, Johann; Kiechl, Stefan; Xu, Qingbo.

In: Stroke, Vol. 36, No. 12, 12.2005, p. 2571-2576.

Research output: Contribution to journalArticle

Xiao, Q, Mandal, K, Schett, G, Mayr, M, Wick, G, Oberhollenzer, F, Willeit, J, Kiechl, S & Xu, Q 2005, 'Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: Clinical significance determined in a follow-up study', Stroke, vol. 36, no. 12, pp. 2571-2576. https://doi.org/10.1161/01.STR.0000189632.98944.ab
Xiao, Qingzhong ; Mandal, Kaushik ; Schett, Georg ; Mayr, Manuel ; Wick, Georg ; Oberhollenzer, Friedrich ; Willeit, Johann ; Kiechl, Stefan ; Xu, Qingbo. / Association of serum-soluble heat shock protein 60 with carotid atherosclerosis : Clinical significance determined in a follow-up study. In: Stroke. 2005 ; Vol. 36, No. 12. pp. 2571-2576.
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AU - Xiao, Qingzhong

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AU - Schett, Georg

AU - Mayr, Manuel

AU - Wick, Georg

AU - Oberhollenzer, Friedrich

AU - Willeit, Johann

AU - Kiechl, Stefan

AU - Xu, Qingbo

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