Association of serum leptin with future left ventricular structure and function

The Multi-Ethnic Study of Atherosclerosis (MESA)

Shishir Sharma, Laura A. Colangelo, Matthew A. Allison, Joao Lima, Bharath Ambale Venkatesh, Satoru Kishi, Kiang Liu, Philip Greenland

Research output: Contribution to journalArticle

Abstract

Abstract Background/objectives Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m2), LV end diastolic volume index (LVEDVi) (-7 ml/m2), LV end systolic volume index (LVESVi) (-3 ml/m2) and stroke volume (-5 ml) (all p ≤ 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3 g/m2), LVEDVi (-1.5 ± 0.4 ml/m2), LVESVi (-0.7 ± 0.2 ml/m2) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05). Conclusions Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.

Original languageEnglish (US)
Article number20538
Pages (from-to)64-68
Number of pages5
JournalInternational Journal of Cardiology
Volume193
DOIs
StatePublished - Jun 11 2015

Fingerprint

Leptin
Left Ventricular Function
Atherosclerosis
Stroke Volume
Serum
Linear Models
Blood Pressure
Asian Americans
Body Surface Area
Adiponectin
Tobacco Use
Hyperlipidemias
Chronic Renal Insufficiency
Hispanic Americans
Antihypertensive Agents
Multicenter Studies
Longitudinal Studies
Regression Analysis
Alcohols

Keywords

  • Adipokine
  • Cardiac structure
  • Left ventricular mass
  • Leptin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of serum leptin with future left ventricular structure and function : The Multi-Ethnic Study of Atherosclerosis (MESA). / Sharma, Shishir; Colangelo, Laura A.; Allison, Matthew A.; Lima, Joao; Ambale Venkatesh, Bharath; Kishi, Satoru; Liu, Kiang; Greenland, Philip.

In: International Journal of Cardiology, Vol. 193, 20538, 11.06.2015, p. 64-68.

Research output: Contribution to journalArticle

Sharma, Shishir ; Colangelo, Laura A. ; Allison, Matthew A. ; Lima, Joao ; Ambale Venkatesh, Bharath ; Kishi, Satoru ; Liu, Kiang ; Greenland, Philip. / Association of serum leptin with future left ventricular structure and function : The Multi-Ethnic Study of Atherosclerosis (MESA). In: International Journal of Cardiology. 2015 ; Vol. 193. pp. 64-68.
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AU - Sharma, Shishir

AU - Colangelo, Laura A.

AU - Allison, Matthew A.

AU - Lima, Joao

AU - Ambale Venkatesh, Bharath

AU - Kishi, Satoru

AU - Liu, Kiang

AU - Greenland, Philip

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N2 - Abstract Background/objectives Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m2), LV end diastolic volume index (LVEDVi) (-7 ml/m2), LV end systolic volume index (LVESVi) (-3 ml/m2) and stroke volume (-5 ml) (all p ≤ 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3 g/m2), LVEDVi (-1.5 ± 0.4 ml/m2), LVESVi (-0.7 ± 0.2 ml/m2) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05). Conclusions Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.

AB - Abstract Background/objectives Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m2), LV end diastolic volume index (LVEDVi) (-7 ml/m2), LV end systolic volume index (LVESVi) (-3 ml/m2) and stroke volume (-5 ml) (all p ≤ 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3 g/m2), LVEDVi (-1.5 ± 0.4 ml/m2), LVESVi (-0.7 ± 0.2 ml/m2) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05). Conclusions Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.

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KW - Cardiac structure

KW - Left ventricular mass

KW - Leptin

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