TY - JOUR
T1 - Association of serum leptin with future left ventricular structure and function
T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Sharma, Shishir
AU - Colangelo, Laura A.
AU - Allison, Matthew A.
AU - Lima, Joao A.C.
AU - Ambale-Venkatesh, Bharath
AU - Kishi, Satoru
AU - Liu, Kiang
AU - Greenland, Philip
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/6/11
Y1 - 2015/6/11
N2 - Abstract Background/objectives Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m2), LV end diastolic volume index (LVEDVi) (-7 ml/m2), LV end systolic volume index (LVESVi) (-3 ml/m2) and stroke volume (-5 ml) (all p ≤ 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3 g/m2), LVEDVi (-1.5 ± 0.4 ml/m2), LVESVi (-0.7 ± 0.2 ml/m2) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05). Conclusions Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.
AB - Abstract Background/objectives Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m2), LV end diastolic volume index (LVEDVi) (-7 ml/m2), LV end systolic volume index (LVESVi) (-3 ml/m2) and stroke volume (-5 ml) (all p ≤ 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3 g/m2), LVEDVi (-1.5 ± 0.4 ml/m2), LVESVi (-0.7 ± 0.2 ml/m2) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05). Conclusions Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.
KW - Adipokine
KW - Cardiac structure
KW - Left ventricular mass
KW - Leptin
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U2 - 10.1016/j.ijcard.2015.05.068
DO - 10.1016/j.ijcard.2015.05.068
M3 - Article
C2 - 26005181
AN - SCOPUS:84930935769
SN - 0167-5273
VL - 193
SP - 64
EP - 68
JO - International Journal of Cardiology
JF - International Journal of Cardiology
M1 - 20538
ER -