TY - JOUR
T1 - Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
AU - Okusaga, Olaoluwa
AU - Yolken, Robert H.
AU - Langenberg, Patricia
AU - Lapidus, Manana
AU - Arling, Timothy A.
AU - Dickerson, Faith B.
AU - Scrandis, Debra A.
AU - Severance, Emily
AU - Cabassa, Johanna A.
AU - Balis, Theodora
AU - Postolache, Teodor T.
N1 - Funding Information:
Funding for this study was provided NARSAD (Independent Investigator Award to T.T.P.), NIH (grants R21 MH075891 and R01MH074891 PI TTP), American Foundation for Suicide Prevention (PI TTP) and the Stanley Medical Research Institute (to F.B.D. and R.H.Y.). The study sponsors had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2011/4
Y1 - 2011/4
N2 - Background: Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking. Methods: Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ2 tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes. Results: Seropositivity for influenza A (p = 0.004), B (p < 0.0001) and coronaviruses (p < 0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p =0.001) and history of psychotic symptoms (p =0.005). Limitations: The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed. Conclusions: The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
AB - Background: Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking. Methods: Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ2 tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes. Results: Seropositivity for influenza A (p = 0.004), B (p < 0.0001) and coronaviruses (p < 0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p =0.001) and history of psychotic symptoms (p =0.005). Limitations: The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed. Conclusions: The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
KW - Coronaviruses
KW - Influenza A and B
KW - Mood disorders
KW - Suicide attempts
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U2 - 10.1016/j.jad.2010.09.029
DO - 10.1016/j.jad.2010.09.029
M3 - Article
C2 - 21030090
AN - SCOPUS:79953200773
SN - 0165-0327
VL - 130
SP - 220
EP - 225
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-2
ER -