Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: The multi-ethnic study of atherosclerosis

Adam C. Naj, Michael West, Stephen S. Rich, Wendy Post, W. H. Linda Kao, Bruce A. Wasserman, David M. Herrington, Annabelle Rodriguez

Research output: Contribution to journalArticle

Abstract

Background-Little is known about the association of scavenger receptor class B type I (SCARB1) single-nucleotide polymorphisms (SNPs) and subclinical atherosclerosis, particularly in subjects of different racial/ethnic backgrounds. We examined this relationship in the Multi-Ethnic Study of Atherosclerosis. Methods and Results-Forty-three SCARB1-tagging SNPs were genotyped. Baseline examinations included fasting lipids and subclinical atherosclerosis phenotypes (coronary artery calcification, common carotid intimal-medial artery thickness [CCIMT], and internal carotid intimal-medial artery thickness). Examining SNP associations with different subclinical atherosclerosis phenotypes across multiple racial/ethnic groups with adjustment for multiple covariates, we found that the C allele of SNP rs10846744 was associated with higher CCIMT in African American (P=0.03), Chinese (P=0.02), European American (P=0.05), and Hispanic participants (P=0.03) and was strongly associated in pooled analyses (P=0.0002). The results also showed that the association of this SNP with CCIMT was independent of lipids and other well-established cardiovascular risk factors. Stratifying by sex, there seemed to be a strong association of rs10846744 with CCIMT in women, but no genotype-sex interactions were observed. Conclusions-Variation in SCARB1 at rs10846744 was significantly associated with CCIMT across racial/ethnic groups in Multi-Ethnic Study of Atherosclerosis.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalCirculation: Cardiovascular Genetics
Volume3
Issue number1
DOIs
StatePublished - Feb 1 2010

Keywords

  • Atherosclerosis
  • Cholesterol
  • Genetic association
  • Genetics
  • Lipids
  • Prospective cohort study

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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