Association of recent HIV infection and in-utero HIV-1 transmission

Taha E Taha, Maria M. James, Donald R. Hoover, Jin Sun, Oliver B. Laeyendecker, Caroline E. Mullis, Johnstone J. Kumwenda, Jairam R. Lingappa, Bertran Auvert, Charles S. Morrison, Lynne M. Mofensen, Allan Taylor, Mary Glenn Fowler, Newton I. Kumenda, Susan Eshleman

Research output: Contribution to journalArticle

Abstract

Objective: We previously developed a multiassay algorithm (MAA) to identify recent HIV infection that includes the BED-capture enzyme immunoassay, an avidity assay based on the Genetic Systems HIV-1/HIV-2+O enzyme immunoassay, CD4 cell count, and HIV viral load. We used this MAA to evaluate the association between recent maternal HIV infection and in-utero transmission of HIV. METHODS:: Plasma samples were collected at delivery from 2561 HIV-infected women in the postexposure prophylaxis of infants-Malawi trial. The MAA described above was used to identify women with recent HIV infection. Logistic regression models assessed association between recent HIV infection and in-utero HIV transmission (defined as a positive infant HIV DNA test at birth). Results: Seventy-three women were identified as recently infected using the MAA. Those women were younger and had lower parity than women who were identified as not recently infected using the MAA (P

Original languageEnglish (US)
Pages (from-to)1357-1364
Number of pages8
JournalAIDS
Volume25
Issue number11
DOIs
StatePublished - Jul 17 2011

Fingerprint

HIV Infections
HIV-1
HIV
Immunoenzyme Techniques
Logistic Models
Malawi
HIV-2
CD4 Lymphocyte Count
Parity
Viral Load
Mothers
Parturition
DNA

Keywords

  • HIV
  • incidence
  • Malawi
  • mother-to-child transmission
  • multiassay algorithm

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Association of recent HIV infection and in-utero HIV-1 transmission. / Taha, Taha E; James, Maria M.; Hoover, Donald R.; Sun, Jin; Laeyendecker, Oliver B.; Mullis, Caroline E.; Kumwenda, Johnstone J.; Lingappa, Jairam R.; Auvert, Bertran; Morrison, Charles S.; Mofensen, Lynne M.; Taylor, Allan; Fowler, Mary Glenn; Kumenda, Newton I.; Eshleman, Susan.

In: AIDS, Vol. 25, No. 11, 17.07.2011, p. 1357-1364.

Research output: Contribution to journalArticle

Taha, TE, James, MM, Hoover, DR, Sun, J, Laeyendecker, OB, Mullis, CE, Kumwenda, JJ, Lingappa, JR, Auvert, B, Morrison, CS, Mofensen, LM, Taylor, A, Fowler, MG, Kumenda, NI & Eshleman, S 2011, 'Association of recent HIV infection and in-utero HIV-1 transmission', AIDS, vol. 25, no. 11, pp. 1357-1364. https://doi.org/10.1097/QAD.0b013e3283489d45
Taha, Taha E ; James, Maria M. ; Hoover, Donald R. ; Sun, Jin ; Laeyendecker, Oliver B. ; Mullis, Caroline E. ; Kumwenda, Johnstone J. ; Lingappa, Jairam R. ; Auvert, Bertran ; Morrison, Charles S. ; Mofensen, Lynne M. ; Taylor, Allan ; Fowler, Mary Glenn ; Kumenda, Newton I. ; Eshleman, Susan. / Association of recent HIV infection and in-utero HIV-1 transmission. In: AIDS. 2011 ; Vol. 25, No. 11. pp. 1357-1364.
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