Association of prenatal antibiotics with foetal size and cord blood leptin and adiponectin

Noel Mueller, S. L. Rifas-Shiman, M. J. Blaser, M. W. Gillman, M. F. Hivert

Research output: Contribution to journalArticle

Abstract

Background: Early postnatal antibiotic use has been shown to promote excess weight gain, but it is unclear whether intrauterine exposure to antibiotics is associated with foetal growth and adiposity. The objective of this study was to examine associations of antibiotic prescription in each trimester of pregnancy with foetal size and adipokine levels at birth. Methods: In 2128 pregnant women from the pre-birth Project Viva cohort, from electronic medical records, we estimated antibiotic prescribing by timing during pregnancy. Outcomes were sex-specific birth weight-for-gestational-age z-score (BW/GA-z) and levels of umbilical cord leptin and adiponectin. We used linear regression models adjusted for maternal age, pre-pregnancy body mass index, parity, race/ethnicity, education, smoking during pregnancy, household income and child sex and additionally adjusted cord blood leptin and adiponectin models for gestation length. Results: Of the 2128 women in our sample, 643 (30.2%) were prescribed with oral antibiotics during pregnancy. Mean (standard deviation) BW/GA-z was 0.17 (0.97), cord blood leptin was 9.0ngmL-1 (6.6) and cord blood adiponectin was 28.8ngmL-1 (6.8). Overall, antibiotic prescription in pregnancy was associated with lower BW/GA-z [multivariable adjusted β -0.11; 95% confidence interval (CI) -0.20, -0.01]. In trimester-specific analyses, only second trimester antibiotic prescription was associated with lower BW/GA-z (β -0.23; 95% CI -0.37, -0.08). Overall, antibiotic prescription in pregnancy was not associated with cord blood leptin or adiponectin levels. However, in trimester-specific analyses, third trimester antibiotic prescription was associated with higher cord blood leptin (β 2.28ngmL-1; 95% CI 0.38, 4.17). Conclusions: Antibiotics in mid-pregnancy were associated with lower birth weight for gestational age, whereas third trimester antibiotics were associated with higher cord blood leptin.

Original languageEnglish (US)
JournalPediatric obesity
DOIs
StateAccepted/In press - 2016

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Adiponectin
Leptin
Fetal Blood
Anti-Bacterial Agents
Pregnancy
Birth Weight
Gestational Age
Prescriptions
Third Pregnancy Trimester
Confidence Intervals
Linear Models
Parturition
Pregnancy Trimesters
Adipokines
Electronic Health Records
Umbilical Cord
Maternal Age
Adiposity
Second Pregnancy Trimester
Fetal Development

Keywords

  • Adiponectin
  • Antibiotics
  • Foetal growth
  • Leptin

ASJC Scopus subject areas

  • Health Policy
  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Nutrition and Dietetics

Cite this

Association of prenatal antibiotics with foetal size and cord blood leptin and adiponectin. / Mueller, Noel; Rifas-Shiman, S. L.; Blaser, M. J.; Gillman, M. W.; Hivert, M. F.

In: Pediatric obesity, 2016.

Research output: Contribution to journalArticle

Mueller, Noel ; Rifas-Shiman, S. L. ; Blaser, M. J. ; Gillman, M. W. ; Hivert, M. F. / Association of prenatal antibiotics with foetal size and cord blood leptin and adiponectin. In: Pediatric obesity. 2016.
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AU - Rifas-Shiman, S. L.

AU - Blaser, M. J.

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AU - Hivert, M. F.

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N2 - Background: Early postnatal antibiotic use has been shown to promote excess weight gain, but it is unclear whether intrauterine exposure to antibiotics is associated with foetal growth and adiposity. The objective of this study was to examine associations of antibiotic prescription in each trimester of pregnancy with foetal size and adipokine levels at birth. Methods: In 2128 pregnant women from the pre-birth Project Viva cohort, from electronic medical records, we estimated antibiotic prescribing by timing during pregnancy. Outcomes were sex-specific birth weight-for-gestational-age z-score (BW/GA-z) and levels of umbilical cord leptin and adiponectin. We used linear regression models adjusted for maternal age, pre-pregnancy body mass index, parity, race/ethnicity, education, smoking during pregnancy, household income and child sex and additionally adjusted cord blood leptin and adiponectin models for gestation length. Results: Of the 2128 women in our sample, 643 (30.2%) were prescribed with oral antibiotics during pregnancy. Mean (standard deviation) BW/GA-z was 0.17 (0.97), cord blood leptin was 9.0ngmL-1 (6.6) and cord blood adiponectin was 28.8ngmL-1 (6.8). Overall, antibiotic prescription in pregnancy was associated with lower BW/GA-z [multivariable adjusted β -0.11; 95% confidence interval (CI) -0.20, -0.01]. In trimester-specific analyses, only second trimester antibiotic prescription was associated with lower BW/GA-z (β -0.23; 95% CI -0.37, -0.08). Overall, antibiotic prescription in pregnancy was not associated with cord blood leptin or adiponectin levels. However, in trimester-specific analyses, third trimester antibiotic prescription was associated with higher cord blood leptin (β 2.28ngmL-1; 95% CI 0.38, 4.17). Conclusions: Antibiotics in mid-pregnancy were associated with lower birth weight for gestational age, whereas third trimester antibiotics were associated with higher cord blood leptin.

AB - Background: Early postnatal antibiotic use has been shown to promote excess weight gain, but it is unclear whether intrauterine exposure to antibiotics is associated with foetal growth and adiposity. The objective of this study was to examine associations of antibiotic prescription in each trimester of pregnancy with foetal size and adipokine levels at birth. Methods: In 2128 pregnant women from the pre-birth Project Viva cohort, from electronic medical records, we estimated antibiotic prescribing by timing during pregnancy. Outcomes were sex-specific birth weight-for-gestational-age z-score (BW/GA-z) and levels of umbilical cord leptin and adiponectin. We used linear regression models adjusted for maternal age, pre-pregnancy body mass index, parity, race/ethnicity, education, smoking during pregnancy, household income and child sex and additionally adjusted cord blood leptin and adiponectin models for gestation length. Results: Of the 2128 women in our sample, 643 (30.2%) were prescribed with oral antibiotics during pregnancy. Mean (standard deviation) BW/GA-z was 0.17 (0.97), cord blood leptin was 9.0ngmL-1 (6.6) and cord blood adiponectin was 28.8ngmL-1 (6.8). Overall, antibiotic prescription in pregnancy was associated with lower BW/GA-z [multivariable adjusted β -0.11; 95% confidence interval (CI) -0.20, -0.01]. In trimester-specific analyses, only second trimester antibiotic prescription was associated with lower BW/GA-z (β -0.23; 95% CI -0.37, -0.08). Overall, antibiotic prescription in pregnancy was not associated with cord blood leptin or adiponectin levels. However, in trimester-specific analyses, third trimester antibiotic prescription was associated with higher cord blood leptin (β 2.28ngmL-1; 95% CI 0.38, 4.17). Conclusions: Antibiotics in mid-pregnancy were associated with lower birth weight for gestational age, whereas third trimester antibiotics were associated with higher cord blood leptin.

KW - Adiponectin

KW - Antibiotics

KW - Foetal growth

KW - Leptin

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