Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection

Chenglong Liu, Mary Carrington, Richard A. Kaslow, Xiaojiang Gao, Charles R. Rinaldo, Lisa Paula Jacobson, Joseph Bernard Margolick, John Phair, Stephen J. O'Brien, Roger Detels

Research output: Contribution to journalArticle

Abstract

To examine the relationship of human leukocyte antigen (HLA) class I and transporter associated with antigen processing (TAP) genes with resistance to human immunodeficiency virus type 1 (HIV-1) infection, 100 HIV-seronegative men who had been exposed repeatedly to HIV-1 were compared with 184 men who had seroconverted to HIV positive and had lower risk. In the univariate analysis, the HLA-A2 supertype, excluding A*0201 (HLA-A2/6802 supertype; odds ratio [OR], 4.45; 95% confidence interval [CI], 1.33-4.84; P = .009) was associated with resistance to HIV-1 infection; the effect was the result of the presence of the A*0205 subgroup alleles. Susceptibility was associated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08-0.99; P = .037), which suggests that differential preferences for amino acids at the C terminus may influence peptide-binding capacity. TAP2 Ala665 was also associated with resistance (OR, 2.26; 95% CI, 1.35-3.79; P = .002), perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8+ T cell response, or because of linkage disequilibrium. In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P = .018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P = .005) were associated with resistance.

Original languageEnglish (US)
Pages (from-to)1404-1410
Number of pages7
JournalJournal of Infectious Diseases
Volume187
Issue number9
DOIs
StatePublished - May 1 2003

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Antigen Presentation
Virus Diseases
HLA Antigens
HIV-1
Odds Ratio
Confidence Intervals
Genes
varespladib methyl
Alleles
HIV
Peptides
Linkage Disequilibrium
Multivariate Analysis
T-Lymphocytes
Amino Acids

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection. / Liu, Chenglong; Carrington, Mary; Kaslow, Richard A.; Gao, Xiaojiang; Rinaldo, Charles R.; Jacobson, Lisa Paula; Margolick, Joseph Bernard; Phair, John; O'Brien, Stephen J.; Detels, Roger.

In: Journal of Infectious Diseases, Vol. 187, No. 9, 01.05.2003, p. 1404-1410.

Research output: Contribution to journalArticle

Liu, Chenglong ; Carrington, Mary ; Kaslow, Richard A. ; Gao, Xiaojiang ; Rinaldo, Charles R. ; Jacobson, Lisa Paula ; Margolick, Joseph Bernard ; Phair, John ; O'Brien, Stephen J. ; Detels, Roger. / Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection. In: Journal of Infectious Diseases. 2003 ; Vol. 187, No. 9. pp. 1404-1410.
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AU - Gao, Xiaojiang

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