@article{51372266002d43b0b3bf0d895ccffbcd,
title = "Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery",
abstract = "Background: Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant post-operative morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) and galectin-3 (gal-3) are biomarkers of myocardial remodeling and fibrosis; however, their potential association with post-operative changes is unknown. Methods: We measured peri-operative plasma sST2 and gal-3 levels in two prospective cohorts (TRIBE-AKI and NNE) of over 1800 patients who underwent cardiac surgery. sST2 and gal-3 levels were evaluated for association with a composite primary outcome of cardiovascular event or mortality over median follow-up periods of 3.4 and 6.0 years, respectively, for the two cohorts. Meta-analysis of hazard ratio estimates from the cohorts was performed using random effects models. Results: Cohorts demonstrated event rates of 70.2 and 66.8 per 1000 person-years for the primary composite outcome. After adjustment for clinical covariates, higher post-operative sST2 and gal-3 levels were significantly associated with cardiovascular event or mortality [pooled estimate HRs: sST2 1.29 (95% CI 1.16, 1.44); gal-3 1.26 (95% CI 1.09, 1.46)]. These associations were not significantly modified by pre-operative congestive heart failure or AKI. Conclusions: Higher post-operative sST2 and gal-3 values were associated with increased incidence of cardiovascular event or mortality. These two biomarkers should be further studied for potential clinical utility for patients undergoing cardiac surgery.",
author = "Patel, {Dipal M.} and Heather Thiessen-Philbrook and Brown, {Jeremiah R.} and Eric McArthur and Moledina, {Dennis G.} and Mansour, {Sherry G.} and Shlipak, {Michael G.} and Koyner, {Jay L.} and Peter Kavsak and Whitlock, {Richard P.} and Everett, {Allen D.} and Malenka, {David J.} and Garg, {Amit X.} and Coca, {Steven G.} and Parikh, {Chirag R.}",
note = "Funding Information: The research reported in this article was supported by the American Heart Association Clinical Development Award, as well as by grant R01HL-085757 from the National Heart, Lung, and Blood Institute. CRP is also supported by an NIH grant (K24DK090203) and by the Yale O'Brien Kidney Center Grant (P30DK079310). SGC, AXG, and CRP are members of the NIH-sponsored Assess, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Consortium (U01DK082185). SGC, MGS, and CRP are members and are supported in part by the Chronic Kidney Disease Biomarker Consortium (1U01DK106962-01). The study was also supported by CTSA Grant Number UL1 RR024139 from the National Center for Research Resources (NCRR). This study was supported by ICES, which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care (MOHLTC); Dr Amit Garg is supported by the Dr Adam Linton Chair in Kidney Health Analytics; there are no other relationships or activities that could appear to have influenced the submitted work. Dr Brown and the NNE Biomarker Study were supported in part by the American Heart Association (0625950T), NHLBI (R01 HL119664), and the Northern New England Cardiovascular Disease Study Group. DGM is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (K23DK117065) and the American Heart Association (18CDA34060118). SGM is supported by the American Heart Association (18CDA34110151). The opinions, results, and conclusions reported in this paper are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the manuscript, and its final contents. Publisher Copyright: {\textcopyright} 2019",
year = "2020",
month = feb,
doi = "10.1016/j.ahj.2019.11.014",
language = "English (US)",
volume = "220",
pages = "253--263",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
}