Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study

Marcello Maggio, Gian Paolo Ceda, Fulvio Lauretani, Stefania Bandinelli, Elisabetta Dall'Aglio, Jack M. Guralnik, Giuseppe Paolisso, Richard D. Semba, Antonio Nouvenne, Loris Borghi, Graziano Ceresini, Fabrizio Ablondi, Mario Benatti, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background & aims: Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods: Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results: Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15)μmol/L and 113.4 (31.2). ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β± SE: 43.76 ± 11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β± SE: 36.7 ± 12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β± SE: 40.1 ± 12.0, p=0.0008). Conclusions: We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.

Original languageEnglish (US)
Pages (from-to)674-677
Number of pages4
JournalClinical Nutrition
Issue number5
StatePublished - Oct 2010


  • Aging
  • Selenium
  • Total IGF-1

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine


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