Background & aims: Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods: Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results: Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15)μmol/L and 113.4 (31.2). ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β± SE: 43.76 ± 11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β± SE: 36.7 ± 12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β± SE: 40.1 ± 12.0, p=0.0008). Conclusions: We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.
- Total IGF-1
ASJC Scopus subject areas
- Nutrition and Dietetics
- Critical Care and Intensive Care Medicine