TY - JOUR
T1 - Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults
T2 - The InCHIANTI study
AU - Maggio, Marcello
AU - Ceda, Gian Paolo
AU - Lauretani, Fulvio
AU - Bandinelli, Stefania
AU - Dall'Aglio, Elisabetta
AU - Guralnik, Jack M.
AU - Paolisso, Giuseppe
AU - Semba, Richard D.
AU - Nouvenne, Antonio
AU - Borghi, Loris
AU - Ceresini, Graziano
AU - Ablondi, Fabrizio
AU - Benatti, Mario
AU - Ferrucci, Luigi
N1 - Funding Information:
This work was supported by National Institute on Aging Contracts N01-AG-916413, N01-AG-821336, N01-AG-5-0002, and NIA Grant R01 AG027012 . This research was supported in part by the Intramural Research Program, National Institute on Aging, NIH.
PY - 2010/10
Y1 - 2010/10
N2 - Background & aims: Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods: Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results: Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15)μmol/L and 113.4 (31.2). ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β± SE: 43.76 ± 11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β± SE: 36.7 ± 12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β± SE: 40.1 ± 12.0, p=0.0008). Conclusions: We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.
AB - Background & aims: Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods: Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results: Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15)μmol/L and 113.4 (31.2). ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β± SE: 43.76 ± 11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β± SE: 36.7 ± 12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β± SE: 40.1 ± 12.0, p=0.0008). Conclusions: We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.
KW - Aging
KW - Selenium
KW - Total IGF-1
UR - http://www.scopus.com/inward/record.url?scp=77957330464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957330464&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2010.03.012
DO - 10.1016/j.clnu.2010.03.012
M3 - Article
C2 - 20416996
AN - SCOPUS:77957330464
SN - 0261-5614
VL - 29
SP - 674
EP - 677
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 5
ER -