TY - JOUR
T1 - Association of plasma retinol levels with incident cancer risk in Chinese hypertensive adults
T2 - A nested case-control study
AU - Xie, Liling
AU - Song, Yun
AU - Lin, Tengfei
AU - Guo, Huiyuan
AU - Wang, Binyan
AU - Tang, Genfu
AU - Liu, Chengzhang
AU - Huang, Weitong
AU - Yang, Yan
AU - Ling, Wenhua
AU - Zhang, Yan
AU - Li, Jianping
AU - Huo, Yong
AU - Wang, Xiaobin
AU - Zhang, Hao
AU - Qin, Xianhui
AU - Xu, Xiping
N1 - Funding Information:
This work was supported by the National Key Research and Development Program (2018ZX09301034003)
Publisher Copyright:
© The Authors 2019.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/8/14
Y1 - 2019/8/14
N2 - We aimed to investigate the association between plasma retinol and incident cancer among Chinese hypertensive adults. We conducted a nested case-control study, including 231 patients with incident cancer and 231 matched controls during a median 4·5-year follow-up of the China Stroke Primary Prevention Trial. There was a significant, inverse association between retinol levels and digestive system cancer (per 10 μg/dl increases: OR 0·79; 95 % CI 0·69, 0·91). When compared with participants in the first quartile of retinol (< 52·3 μg/dl), a significantly lower cancer risk was found in participants in quartile 2-4 ( ≥ 52·3 μg/dl: OR 0·31; 95 % CI 0·13, 0·71). However, there was a U-shaped association between retinol levels and non-digestive system cancers where the risk of cancers decreased (although not significantly) with each increment of plasma retinol (per 10 μg/dl increases: OR 0·89; 95 % CI 0·60, 1·31) in participants with retinol < 68·2 μg/dl, and then increased significantly with retinol (per 10 μg/dl increase: OR 1·65; 95 % CI 1·12, 2·44) in participants with retinol ≥ 68·2 μg/dl. In conclusion, there was a significant inverse dose-response association between plasma retinol and the risk of digestive system cancers. However, a U-shaped association was observed between plasma retinol and the risk of non-digestive cancers (with a turning point approximately 68·2 μg/dl).
AB - We aimed to investigate the association between plasma retinol and incident cancer among Chinese hypertensive adults. We conducted a nested case-control study, including 231 patients with incident cancer and 231 matched controls during a median 4·5-year follow-up of the China Stroke Primary Prevention Trial. There was a significant, inverse association between retinol levels and digestive system cancer (per 10 μg/dl increases: OR 0·79; 95 % CI 0·69, 0·91). When compared with participants in the first quartile of retinol (< 52·3 μg/dl), a significantly lower cancer risk was found in participants in quartile 2-4 ( ≥ 52·3 μg/dl: OR 0·31; 95 % CI 0·13, 0·71). However, there was a U-shaped association between retinol levels and non-digestive system cancers where the risk of cancers decreased (although not significantly) with each increment of plasma retinol (per 10 μg/dl increases: OR 0·89; 95 % CI 0·60, 1·31) in participants with retinol < 68·2 μg/dl, and then increased significantly with retinol (per 10 μg/dl increase: OR 1·65; 95 % CI 1·12, 2·44) in participants with retinol ≥ 68·2 μg/dl. In conclusion, there was a significant inverse dose-response association between plasma retinol and the risk of digestive system cancers. However, a U-shaped association was observed between plasma retinol and the risk of non-digestive cancers (with a turning point approximately 68·2 μg/dl).
KW - Digestive cancers
KW - Hypertensive populations
KW - Non-digestive cancers
KW - Retinol
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U2 - 10.1017/S000711451900120X
DO - 10.1017/S000711451900120X
M3 - Article
C2 - 31352906
AN - SCOPUS:85069904058
VL - 122
SP - 293
EP - 300
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 3
ER -