Association of plasma proteins with rate of cognitive decline and dementia: 20-year follow-up of the Whitehall II and ARIC cohort studies

Joni V. Lindbohm, Nina Mars, Keenan A. Walker, Archana Singh-Manoux, Gill Livingston, Eric J. Brunner, Pyry N. Sipilä, Kalle Saksela, Jane E. Ferrie, Ruth Lovering, Stephen A. Williams, Aroon D. Hingorani, Rebecca F. Gottesman, Henrik Zetterberg, Mika Kivimäki

Research output: Contribution to journalArticlepeer-review

Abstract

The role of circulating proteins in Alzheimer’s disease and related dementias is unknown. Using a follow-up of two decades, 4953 plasma proteins, and discovery (Whitehall II) and replication cohort (ARIC), we examined plasma proteins associated with cognitive decline rate and dementia. After replication and adjustment for known dementia risk factors, fifteen proteins were associated with cognitive decline rate and dementia. None of these were amyloid, tau, or neurofilament-related proteins. Currently approved medications can target five of the proteins. The results support systemic pathogenesis of dementias, may aid in early diagnosis, and suggest potential targets for drug development.

Original languageEnglish (US)
JournalUnknown Journal
DOIs
StatePublished - Nov 20 2020

ASJC Scopus subject areas

  • Medicine(all)

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