Association of plasma omega-3 and omega-6 lipids with burden of disease measures in bipolar subjects

Simon J. Evans, Masoud Kamali, Alan R. Prossin, Gloria J. Harrington, Vicki L. Ellingrod, Melvin G. McInnis, Charles F. Burant

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Omega-3 (n-3) fatty acids have been implicated in mood disorders, yet clinical trials supplementing n-3 fats have shown mixed results. However, the predominant focus of this research has been on the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). We used an unbiased approach to assay plasma n-3 and omega-6 (n-6) species that interact at the level of biosynthesis and down-stream processing, to affect brain function and, potentially, mood. We used lipomic technology to assay plasma levels of n-3 and n-6 fatty acids from 40 bipolar and 18 control subjects to investigate differences in plasma levels and associations with the burden of disease markers, neuroticism and global assessment of function (GAF) and mood state (Hamilton Depression Scale (HAM-D)). Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA). These associations remained significant following Bonferroni multiple testing correction. These data suggest that specific n-6 fatty acids and the enzymes that control their biosynthesis may be useful biomarkers in measurements of depressive disorders and burden of disease, and that they should be considered when investigating the roles of n-3s.

    Original languageEnglish (US)
    Pages (from-to)1435-1441
    Number of pages7
    JournalJournal of Psychiatric Research
    Volume46
    Issue number11
    DOIs
    StatePublished - Nov 2012

    Keywords

    • Dihomogamma linolenic acid
    • Fatty acid desaturase
    • Global assessment of function
    • Neuroticism
    • Omega-3 fatty acids
    • Omega-6 fatty acids

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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