Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents

Shanchun Zhang, Xin Liu, Wendy J. Brickman, Katherine Kaufer Christoffel, Donald Zimmerman, Hui Ju Tsai, Guoying Wang, Binyan Wang, Zhiping Li, Gengfu Tang, Xue Liu, Jianhua Yang, Xiping Xu, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

Context: There is evidence that leptin is involved in the etiology of obesity-related cardiovascular disease in adults. This raises the question of whether leptin levels in adolescence are indicative of adiposity-related cardiovascular risk. Objective: This study investigated gender-specific patterns of plasma leptin during adolescence, assessed which adiposity measurements are most strongly associated with plasma leptin, and estimated to what degree leptin-adiposity associations are influenced by genetic factors. Methods: Plasma leptin concentrations were determined using a sandwich immunoassay. Associations between plasma leptin and several adiposity measurements were examined using generalized estimating equations. Genetic contribution to leptin-adiposity association was estimated by Cholesky decomposition models using twin design. Results: Plasma leptin levels were higher in females than males at all Tanner stages. In females, body mass index, waist circumference, fat mass index (FMI), and percentage body fat (%BF) had similar associations with leptin levels. In males, %BF and FMI were more strongly associated with leptin levels than body mass index and waist circumference. In both males and females, percentage trunk fat had the weakest association with leptin among the five adiposity measures. Shared genetic factors account for more than 80% of the phenotypic correlation between %BF and leptin. Conclusions: We found gender differences in leptin levels and leptin-adiposity associations. In both genders, leptin levels were strongly associated with %BF and FMI, particularly in males. Shared genetic factors contributed largely to the phenotypic correlation between leptin and %BF. Our findings underscored the importance of further investigation of leptin as a biomarker of adiposity in adolescents.

Original languageEnglish (US)
Pages (from-to)3497-3504
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number9
DOIs
StatePublished - Sep 2009
Externally publishedYes

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Adiposity
Leptin
Plasmas
Fats
Waist Circumference
Body Mass Index
Association reactions
Biomarkers

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents. / Zhang, Shanchun; Liu, Xin; Brickman, Wendy J.; Christoffel, Katherine Kaufer; Zimmerman, Donald; Tsai, Hui Ju; Wang, Guoying; Wang, Binyan; Li, Zhiping; Tang, Gengfu; Liu, Xue; Yang, Jianhua; Xu, Xiping; Wang, Xiaobin.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 9, 09.2009, p. 3497-3504.

Research output: Contribution to journalArticle

Zhang, S, Liu, X, Brickman, WJ, Christoffel, KK, Zimmerman, D, Tsai, HJ, Wang, G, Wang, B, Li, Z, Tang, G, Liu, X, Yang, J, Xu, X & Wang, X 2009, 'Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 9, pp. 3497-3504. https://doi.org/10.1210/jc.2009-1060
Zhang, Shanchun ; Liu, Xin ; Brickman, Wendy J. ; Christoffel, Katherine Kaufer ; Zimmerman, Donald ; Tsai, Hui Ju ; Wang, Guoying ; Wang, Binyan ; Li, Zhiping ; Tang, Gengfu ; Liu, Xue ; Yang, Jianhua ; Xu, Xiping ; Wang, Xiaobin. / Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 9. pp. 3497-3504.
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abstract = "Context: There is evidence that leptin is involved in the etiology of obesity-related cardiovascular disease in adults. This raises the question of whether leptin levels in adolescence are indicative of adiposity-related cardiovascular risk. Objective: This study investigated gender-specific patterns of plasma leptin during adolescence, assessed which adiposity measurements are most strongly associated with plasma leptin, and estimated to what degree leptin-adiposity associations are influenced by genetic factors. Methods: Plasma leptin concentrations were determined using a sandwich immunoassay. Associations between plasma leptin and several adiposity measurements were examined using generalized estimating equations. Genetic contribution to leptin-adiposity association was estimated by Cholesky decomposition models using twin design. Results: Plasma leptin levels were higher in females than males at all Tanner stages. In females, body mass index, waist circumference, fat mass index (FMI), and percentage body fat ({\%}BF) had similar associations with leptin levels. In males, {\%}BF and FMI were more strongly associated with leptin levels than body mass index and waist circumference. In both males and females, percentage trunk fat had the weakest association with leptin among the five adiposity measures. Shared genetic factors account for more than 80{\%} of the phenotypic correlation between {\%}BF and leptin. Conclusions: We found gender differences in leptin levels and leptin-adiposity associations. In both genders, leptin levels were strongly associated with {\%}BF and FMI, particularly in males. Shared genetic factors contributed largely to the phenotypic correlation between leptin and {\%}BF. Our findings underscored the importance of further investigation of leptin as a biomarker of adiposity in adolescents.",
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AU - Liu, Xin

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AU - Zimmerman, Donald

AU - Tsai, Hui Ju

AU - Wang, Guoying

AU - Wang, Binyan

AU - Li, Zhiping

AU - Tang, Gengfu

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AU - Yang, Jianhua

AU - Xu, Xiping

AU - Wang, Xiaobin

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N2 - Context: There is evidence that leptin is involved in the etiology of obesity-related cardiovascular disease in adults. This raises the question of whether leptin levels in adolescence are indicative of adiposity-related cardiovascular risk. Objective: This study investigated gender-specific patterns of plasma leptin during adolescence, assessed which adiposity measurements are most strongly associated with plasma leptin, and estimated to what degree leptin-adiposity associations are influenced by genetic factors. Methods: Plasma leptin concentrations were determined using a sandwich immunoassay. Associations between plasma leptin and several adiposity measurements were examined using generalized estimating equations. Genetic contribution to leptin-adiposity association was estimated by Cholesky decomposition models using twin design. Results: Plasma leptin levels were higher in females than males at all Tanner stages. In females, body mass index, waist circumference, fat mass index (FMI), and percentage body fat (%BF) had similar associations with leptin levels. In males, %BF and FMI were more strongly associated with leptin levels than body mass index and waist circumference. In both males and females, percentage trunk fat had the weakest association with leptin among the five adiposity measures. Shared genetic factors account for more than 80% of the phenotypic correlation between %BF and leptin. Conclusions: We found gender differences in leptin levels and leptin-adiposity associations. In both genders, leptin levels were strongly associated with %BF and FMI, particularly in males. Shared genetic factors contributed largely to the phenotypic correlation between leptin and %BF. Our findings underscored the importance of further investigation of leptin as a biomarker of adiposity in adolescents.

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