Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease

Mark Yarchoan; Natalia Louneva; Sharon X. Xie; Frank J. Swenson; William Hu; Holly Soares; John Q. Trojanowski; Virginia M.Y. Lee; Mitchel A. Kling; Leslie M. Shaw; Alice Chen-Plotkin; David A. Wolk; Steven E. Arnold

doi:10.1016/j.jns.2013.05.028

Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease

Mark Yarchoan, Natalia Louneva, Sharon X. Xie, Frank J. Swenson, William Hu, Holly Soares, John Q. Trojanowski, Virginia M.Y. Lee, Mitchel A. Kling, Leslie M. Shaw, Alice Chen-Plotkin, David A. Wolk, Steven E. Arnold

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	333
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2013.05.028
State	Published - Oct 15 2013
Externally published	Yes

Keywords

Alzheimer disease
Apolipoprotein E
Biological markers
C-reactive protein
Inflammation
Mild cognitive impairment

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.jns.2013.05.028

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Yarchoan, M., Louneva, N., Xie, S. X., Swenson, F. J., Hu, W., Soares, H., Trojanowski, J. Q., Lee, V. M. Y., Kling, M. A., Shaw, L. M., Chen-Plotkin, A., Wolk, D. A., & Arnold, S. E. (2013). Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. Journal of the Neurological Sciences, 333(1-2), 9-12. https://doi.org/10.1016/j.jns.2013.05.028

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title = "Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease",

abstract = "C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD.",

keywords = "Alzheimer disease, Apolipoprotein E, Biological markers, C-reactive protein, Inflammation, Mild cognitive impairment",

author = "Mark Yarchoan and Natalia Louneva and Xie, {Sharon X.} and Swenson, {Frank J.} and William Hu and Holly Soares and Trojanowski, {John Q.} and Lee, {Virginia M.Y.} and Kling, {Mitchel A.} and Shaw, {Leslie M.} and Alice Chen-Plotkin and Wolk, {David A.} and Arnold, {Steven E.}",

note = "Funding Information: This study has been supported by the National Institutes of Health (grant no. AG10124 ), the Penn-Pfizer Research Alliance at the University of Pennsylvania, the Marian S. Ware Alzheimer's Program, and the Allen H. and Selma W. Berkman Charitable Trust. We thank Xiaoyan Han, M.S., for her help with the statistical programming of the mixed-effects model analysis.",

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doi = "10.1016/j.jns.2013.05.028",

language = "English (US)",

volume = "333",

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issn = "0022-510X",

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AU - Yarchoan, Mark

AU - Louneva, Natalia

AU - Xie, Sharon X.

AU - Swenson, Frank J.

AU - Hu, William

AU - Soares, Holly

AU - Trojanowski, John Q.

AU - Lee, Virginia M.Y.

AU - Kling, Mitchel A.

AU - Shaw, Leslie M.

AU - Chen-Plotkin, Alice

AU - Wolk, David A.

AU - Arnold, Steven E.

N1 - Funding Information: This study has been supported by the National Institutes of Health (grant no. AG10124 ), the Penn-Pfizer Research Alliance at the University of Pennsylvania, the Marian S. Ware Alzheimer's Program, and the Allen H. and Selma W. Berkman Charitable Trust. We thank Xiaoyan Han, M.S., for her help with the statistical programming of the mixed-effects model analysis.

PY - 2013/10/15

Y1 - 2013/10/15

N2 - C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD.

AB - C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD.

KW - Alzheimer disease

KW - Apolipoprotein E

KW - Biological markers

KW - C-reactive protein

KW - Inflammation

KW - Mild cognitive impairment

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Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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