Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease

Mark Yarchoan, Natalia Louneva, Sharon X. Xie, Frank J. Swenson, William Hu, Holly Soares, John Q. Trojanowski, Virginia M.Y. Lee, Mitchel A. Kling, Leslie M. Shaw, Alice Chen-Plotkin, David A. Wolk, Steven E. Arnold

Research output: Contribution to journalArticlepeer-review

Abstract

C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalJournal of the Neurological Sciences
Volume333
Issue number1-2
DOIs
StatePublished - Oct 15 2013
Externally publishedYes

Keywords

  • Alzheimer disease
  • Apolipoprotein E
  • Biological markers
  • C-reactive protein
  • Inflammation
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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