Association of physical activity and body composition with insulin sensitivity in a community sample of adolescents

Soren Snitker, Katherine Y. Le, Erin Hager, Benjamin H Caballero, Maureen M. Black

Research output: Contribution to journalArticle

Abstract

Objective: To examine how body composition and physical activity are related to insulin sensitivity and secretion in adolescents. Design: Cross-sectional. Setting: Baltimore, Maryland. Participants: Fifty-six healthy adolescents (34 boys and 22 girls; mean [SD] age, 13.3 [1.3] years; 95% were African American) who had been recruited at infancy from a health care clinic serving a low-income, urban community. Main Exposures: Physical activity was measured for 5 to 7 days by a uniaxial accelerometer placed on the right ankle. Proportion of time spent in play-equivalent physical activity (PEPA) was defined as 1800 or more counts per minute. Body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) was converted to an age- and sex-specific z score. Main Outcome Measures: Insulin sensitivity, insulin secretion, and disposition index calculated from a fasting oral glucose tolerance test. Results: Thirty-nine percent of the adolescents had a BMI in the 85th percentile or higher; half of those were overweight (BMI≥95th percentile). Play-equivalent physical activity and BMI z score were not correlated. In multivariate analyses, BMI z score and time spent in PEPA together explained 21% of the variance in insulin sensitivity and 18% in insulin secretion. Independent of each other, high BMI z score and low proportion of PEPA were significantly associated with low insulin sensitivity (partial r 2=0.14 and 0.10, respectively) and high insulin secretion (partial r2=0.10 and 0.10, respectively), but not with disposition index. Conclusions: In a cohort of urban, predominantly African American adolescents, both body composition and physical activity were independently associated with insulin sensitivity. At this point, insulin secretion is appropriately regulated.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalArchives of Pediatrics and Adolescent Medicine
Volume161
Issue number7
DOIs
StatePublished - Jul 2007

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Body Composition
Insulin Resistance
Exercise
Body Mass Index
Insulin
African Americans
Baltimore
Glucose Tolerance Test
Ankle
Fasting
Multivariate Analysis
Outcome Assessment (Health Care)
Delivery of Health Care
Weights and Measures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Association of physical activity and body composition with insulin sensitivity in a community sample of adolescents. / Snitker, Soren; Le, Katherine Y.; Hager, Erin; Caballero, Benjamin H; Black, Maureen M.

In: Archives of Pediatrics and Adolescent Medicine, Vol. 161, No. 7, 07.2007, p. 677-683.

Research output: Contribution to journalArticle

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abstract = "Objective: To examine how body composition and physical activity are related to insulin sensitivity and secretion in adolescents. Design: Cross-sectional. Setting: Baltimore, Maryland. Participants: Fifty-six healthy adolescents (34 boys and 22 girls; mean [SD] age, 13.3 [1.3] years; 95{\%} were African American) who had been recruited at infancy from a health care clinic serving a low-income, urban community. Main Exposures: Physical activity was measured for 5 to 7 days by a uniaxial accelerometer placed on the right ankle. Proportion of time spent in play-equivalent physical activity (PEPA) was defined as 1800 or more counts per minute. Body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) was converted to an age- and sex-specific z score. Main Outcome Measures: Insulin sensitivity, insulin secretion, and disposition index calculated from a fasting oral glucose tolerance test. Results: Thirty-nine percent of the adolescents had a BMI in the 85th percentile or higher; half of those were overweight (BMI≥95th percentile). Play-equivalent physical activity and BMI z score were not correlated. In multivariate analyses, BMI z score and time spent in PEPA together explained 21{\%} of the variance in insulin sensitivity and 18{\%} in insulin secretion. Independent of each other, high BMI z score and low proportion of PEPA were significantly associated with low insulin sensitivity (partial r 2=0.14 and 0.10, respectively) and high insulin secretion (partial r2=0.10 and 0.10, respectively), but not with disposition index. Conclusions: In a cohort of urban, predominantly African American adolescents, both body composition and physical activity were independently associated with insulin sensitivity. At this point, insulin secretion is appropriately regulated.",
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