Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline

Andreea M. Rawlings, Stephen P. Juraschek, Gerardo Heiss, Timothy Hughes, Michelle L. Meyer, Elizabeth Selvin, A. Richey Sharrett, B. Gwen Windham, Rebecca F Gottesman

Research output: Contribution to journalArticle

Abstract

Objective To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. Methods We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a drop in systolic blood pressure (BP) of at least 20 mm Hg or a drop in diastolic BP of at least 10 mm Hg on standing. Dementia was ascertained via examination, contact with participants or their proxy, or medical record surveillance. Ischemic stroke was ascertained via cohort surveillance of hospitalizations, cohort follow-up, and linkage with registries. Both outcomes were adjudicated. Cognitive function was ascertained via 3 neuropsychological tests administered in 1990 to 1992 and 1996 to 1998 and a full battery of tests in 2011 to 2013. Scores were summarized and reported as SDs. We used adjusted Cox regression and linear mixed models. Results Over ∼25 years, 1,068 participants developed dementia and 842 had an ischemic stroke. Compared to persons without OH at baseline, those with OH had a higher risk of dementia (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.20-1.97) and ischemic stroke (HR 2.08, 95% CI 1.65-2.62). Persons with OH had greater, although nonsignificant, cognitive decline over 20 years (SD 0.09, 95% CI-0.02 to 0.21). Conclusions OH assessed in midlife was independently associated with incident dementia and ischemic stroke. Additional studies are needed to elucidate potential mechanisms for these associations and possible applications for prevention.

Original languageEnglish (US)
Pages (from-to)e759-e768
JournalNeurology
Volume91
Issue number8
DOIs
StatePublished - Aug 21 2018

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Orthostatic Hypotension
Dementia
Stroke
Blood Pressure
Confidence Intervals
Neuropsychological Tests
Proxy
Cognition
Medical Records
Coronary Disease
Registries
Cognitive Dysfunction
Linear Models
Atherosclerosis
Hospitalization

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline. / Rawlings, Andreea M.; Juraschek, Stephen P.; Heiss, Gerardo; Hughes, Timothy; Meyer, Michelle L.; Selvin, Elizabeth; Sharrett, A. Richey; Windham, B. Gwen; Gottesman, Rebecca F.

In: Neurology, Vol. 91, No. 8, 21.08.2018, p. e759-e768.

Research output: Contribution to journalArticle

Rawlings, AM, Juraschek, SP, Heiss, G, Hughes, T, Meyer, ML, Selvin, E, Sharrett, AR, Windham, BG & Gottesman, RF 2018, 'Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline', Neurology, vol. 91, no. 8, pp. e759-e768. https://doi.org/10.1212/WNL.0000000000006027
Rawlings, Andreea M. ; Juraschek, Stephen P. ; Heiss, Gerardo ; Hughes, Timothy ; Meyer, Michelle L. ; Selvin, Elizabeth ; Sharrett, A. Richey ; Windham, B. Gwen ; Gottesman, Rebecca F. / Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline. In: Neurology. 2018 ; Vol. 91, No. 8. pp. e759-e768.
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abstract = "Objective To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. Methods We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a drop in systolic blood pressure (BP) of at least 20 mm Hg or a drop in diastolic BP of at least 10 mm Hg on standing. Dementia was ascertained via examination, contact with participants or their proxy, or medical record surveillance. Ischemic stroke was ascertained via cohort surveillance of hospitalizations, cohort follow-up, and linkage with registries. Both outcomes were adjudicated. Cognitive function was ascertained via 3 neuropsychological tests administered in 1990 to 1992 and 1996 to 1998 and a full battery of tests in 2011 to 2013. Scores were summarized and reported as SDs. We used adjusted Cox regression and linear mixed models. Results Over ∼25 years, 1,068 participants developed dementia and 842 had an ischemic stroke. Compared to persons without OH at baseline, those with OH had a higher risk of dementia (hazard ratio [HR] 1.54, 95{\%} confidence interval [CI] 1.20-1.97) and ischemic stroke (HR 2.08, 95{\%} CI 1.65-2.62). Persons with OH had greater, although nonsignificant, cognitive decline over 20 years (SD 0.09, 95{\%} CI-0.02 to 0.21). Conclusions OH assessed in midlife was independently associated with incident dementia and ischemic stroke. Additional studies are needed to elucidate potential mechanisms for these associations and possible applications for prevention.",
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T1 - Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline

AU - Rawlings, Andreea M.

AU - Juraschek, Stephen P.

AU - Heiss, Gerardo

AU - Hughes, Timothy

AU - Meyer, Michelle L.

AU - Selvin, Elizabeth

AU - Sharrett, A. Richey

AU - Windham, B. Gwen

AU - Gottesman, Rebecca F

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N2 - Objective To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. Methods We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a drop in systolic blood pressure (BP) of at least 20 mm Hg or a drop in diastolic BP of at least 10 mm Hg on standing. Dementia was ascertained via examination, contact with participants or their proxy, or medical record surveillance. Ischemic stroke was ascertained via cohort surveillance of hospitalizations, cohort follow-up, and linkage with registries. Both outcomes were adjudicated. Cognitive function was ascertained via 3 neuropsychological tests administered in 1990 to 1992 and 1996 to 1998 and a full battery of tests in 2011 to 2013. Scores were summarized and reported as SDs. We used adjusted Cox regression and linear mixed models. Results Over ∼25 years, 1,068 participants developed dementia and 842 had an ischemic stroke. Compared to persons without OH at baseline, those with OH had a higher risk of dementia (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.20-1.97) and ischemic stroke (HR 2.08, 95% CI 1.65-2.62). Persons with OH had greater, although nonsignificant, cognitive decline over 20 years (SD 0.09, 95% CI-0.02 to 0.21). Conclusions OH assessed in midlife was independently associated with incident dementia and ischemic stroke. Additional studies are needed to elucidate potential mechanisms for these associations and possible applications for prevention.

AB - Objective To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. Methods We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a drop in systolic blood pressure (BP) of at least 20 mm Hg or a drop in diastolic BP of at least 10 mm Hg on standing. Dementia was ascertained via examination, contact with participants or their proxy, or medical record surveillance. Ischemic stroke was ascertained via cohort surveillance of hospitalizations, cohort follow-up, and linkage with registries. Both outcomes were adjudicated. Cognitive function was ascertained via 3 neuropsychological tests administered in 1990 to 1992 and 1996 to 1998 and a full battery of tests in 2011 to 2013. Scores were summarized and reported as SDs. We used adjusted Cox regression and linear mixed models. Results Over ∼25 years, 1,068 participants developed dementia and 842 had an ischemic stroke. Compared to persons without OH at baseline, those with OH had a higher risk of dementia (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.20-1.97) and ischemic stroke (HR 2.08, 95% CI 1.65-2.62). Persons with OH had greater, although nonsignificant, cognitive decline over 20 years (SD 0.09, 95% CI-0.02 to 0.21). Conclusions OH assessed in midlife was independently associated with incident dementia and ischemic stroke. Additional studies are needed to elucidate potential mechanisms for these associations and possible applications for prevention.

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